IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.

The ability to tolerate Candida albicans, a human commensal of the gastrointestinal tract and vagina, implicates that host defense mechanisms of resistance and tolerance cooperate to limit fungal burden and inflammation at the different body sites. We evaluated resistance and tolerance to the fungus...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Antonella De Luca, Agostinho Carvalho, Cristina Cunha, Rossana G Iannitti, Lucia Pitzurra, Gloria Giovannini, Antonella Mencacci, Lorenzo Bartolommei, Silvia Moretti, Cristina Massi-Benedetti, Dietmar Fuchs, Flavia De Bernardis, Paolo Puccetti, Luigina Romani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d22729873d10418789d2965973ef57e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d22729873d10418789d2965973ef57e2
record_format	dspace
spelling	oai:doaj.org-article:d22729873d10418789d2965973ef57e22021-12-02T19:59:40ZIL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.1553-73661553-737410.1371/journal.ppat.1003486https://doaj.org/article/d22729873d10418789d2965973ef57e22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23853597/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The ability to tolerate Candida albicans, a human commensal of the gastrointestinal tract and vagina, implicates that host defense mechanisms of resistance and tolerance cooperate to limit fungal burden and inflammation at the different body sites. We evaluated resistance and tolerance to the fungus in experimental and human vulvovaginal candidiasis (VVC) as well as in recurrent VVC (RVVC). Resistance and tolerance mechanisms were both activated in murine VVC, involving IL-22 and IL-10-producing regulatory T cells, respectively, with a major contribution by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1). IDO1 was responsible for the production of tolerogenic kynurenines, such that replacement therapy with kynurenines restored immunoprotection to VVC. In humans, two functional genetic variants in IL22 and IDO1 genes were found to be associated with heightened resistance to RVVC, and they correlated with increased local expression of IL-22, IDO1 and kynurenines. Thus, IL-22 and IDO1 are crucial in balancing resistance with tolerance to Candida, their deficiencies are risk factors for RVVC, and targeting tolerance via therapeutic kynurenines may benefit patients with RVVC.Antonella De LucaAgostinho CarvalhoCristina CunhaRossana G IannittiLucia PitzurraGloria GiovanniniAntonella MencacciLorenzo BartolommeiSilvia MorettiCristina Massi-BenedettiDietmar FuchsFlavia De BernardisPaolo PuccettiLuigina RomaniPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 7, p e1003486 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Antonella De Luca Agostinho Carvalho Cristina Cunha Rossana G Iannitti Lucia Pitzurra Gloria Giovannini Antonella Mencacci Lorenzo Bartolommei Silvia Moretti Cristina Massi-Benedetti Dietmar Fuchs Flavia De Bernardis Paolo Puccetti Luigina Romani IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
description	The ability to tolerate Candida albicans, a human commensal of the gastrointestinal tract and vagina, implicates that host defense mechanisms of resistance and tolerance cooperate to limit fungal burden and inflammation at the different body sites. We evaluated resistance and tolerance to the fungus in experimental and human vulvovaginal candidiasis (VVC) as well as in recurrent VVC (RVVC). Resistance and tolerance mechanisms were both activated in murine VVC, involving IL-22 and IL-10-producing regulatory T cells, respectively, with a major contribution by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1). IDO1 was responsible for the production of tolerogenic kynurenines, such that replacement therapy with kynurenines restored immunoprotection to VVC. In humans, two functional genetic variants in IL22 and IDO1 genes were found to be associated with heightened resistance to RVVC, and they correlated with increased local expression of IL-22, IDO1 and kynurenines. Thus, IL-22 and IDO1 are crucial in balancing resistance with tolerance to Candida, their deficiencies are risk factors for RVVC, and targeting tolerance via therapeutic kynurenines may benefit patients with RVVC.
format	article
author	Antonella De Luca Agostinho Carvalho Cristina Cunha Rossana G Iannitti Lucia Pitzurra Gloria Giovannini Antonella Mencacci Lorenzo Bartolommei Silvia Moretti Cristina Massi-Benedetti Dietmar Fuchs Flavia De Bernardis Paolo Puccetti Luigina Romani
author_facet	Antonella De Luca Agostinho Carvalho Cristina Cunha Rossana G Iannitti Lucia Pitzurra Gloria Giovannini Antonella Mencacci Lorenzo Bartolommei Silvia Moretti Cristina Massi-Benedetti Dietmar Fuchs Flavia De Bernardis Paolo Puccetti Luigina Romani
author_sort	Antonella De Luca
title	IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
title_short	IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
title_full	IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
title_fullStr	IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
title_full_unstemmed	IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
title_sort	il-22 and ido1 affect immunity and tolerance to murine and human vaginal candidiasis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d22729873d10418789d2965973ef57e2
work_keys_str_mv	AT antonelladeluca il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT agostinhocarvalho il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT cristinacunha il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT rossanagiannitti il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT luciapitzurra il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT gloriagiovannini il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT antonellamencacci il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT lorenzobartolommei il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT silviamoretti il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT cristinamassibenedetti il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT dietmarfuchs il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT flaviadebernardis il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT paolopuccetti il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis AT luiginaromani il22andido1affectimmunityandtolerancetomurineandhumanvaginalcandidiasis
_version_	1718375748991975424

IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.

Ejemplares similares