Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma

Fumarate hydratase (FH) is an important enzymatic component in the tricarboxylic acid cycle. Studies have reported that FH plays an important role in hereditary leiomyomatosis and renal cell cancer (HLRCC). However, the role of FH in human different cancers remains unknown. This study is aimed at an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Heng Zhang, Qiang Ju, Jing Ji, Yanjie Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d2278ae5af0645878401f4acd53e86f5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d2278ae5af0645878401f4acd53e86f5
record_format	dspace
spelling	oai:doaj.org-article:d2278ae5af0645878401f4acd53e86f52021-11-08T02:35:16ZPan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma1875-863010.1155/2021/8554844https://doaj.org/article/d2278ae5af0645878401f4acd53e86f52021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8554844https://doaj.org/toc/1875-8630Fumarate hydratase (FH) is an important enzymatic component in the tricarboxylic acid cycle. Studies have reported that FH plays an important role in hereditary leiomyomatosis and renal cell cancer (HLRCC). However, the role of FH in human different cancers remains unknown. This study is aimed at analyzing the prognostic value of FH and demonstrating the correlation between FH expression and tumor immunity. Results showed that FH was mutated or copy number varied in 27 types of cancer. FH mRNA was abnormally upregulated across various cancers. Survival analysis suggested high expression of FH was associated with poor prognosis in many cancer types, including lung adenocarcinoma (LUAD). Additionally, FH expression was associated with immune infiltration, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells, especially in liver hepatocellular carcinoma (LIHC), LUAD, and lung squamous cell carcinoma (LUSC). Moreover, FH expression showed a strong correlation with immune checkpoint markers in LUAD and testicular germ cell tumors (TGCT). These results indicate that FH is an immunotherapeutic target and a potential prognostic biomarker in LUAD.Heng ZhangQiang JuJing JiYanjie ZhaoHindawi LimitedarticleMedicine (General)R5-920ENDisease Markers, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Heng Zhang Qiang Ju Jing Ji Yanjie Zhao Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma
description	Fumarate hydratase (FH) is an important enzymatic component in the tricarboxylic acid cycle. Studies have reported that FH plays an important role in hereditary leiomyomatosis and renal cell cancer (HLRCC). However, the role of FH in human different cancers remains unknown. This study is aimed at analyzing the prognostic value of FH and demonstrating the correlation between FH expression and tumor immunity. Results showed that FH was mutated or copy number varied in 27 types of cancer. FH mRNA was abnormally upregulated across various cancers. Survival analysis suggested high expression of FH was associated with poor prognosis in many cancer types, including lung adenocarcinoma (LUAD). Additionally, FH expression was associated with immune infiltration, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells, especially in liver hepatocellular carcinoma (LIHC), LUAD, and lung squamous cell carcinoma (LUSC). Moreover, FH expression showed a strong correlation with immune checkpoint markers in LUAD and testicular germ cell tumors (TGCT). These results indicate that FH is an immunotherapeutic target and a potential prognostic biomarker in LUAD.
format	article
author	Heng Zhang Qiang Ju Jing Ji Yanjie Zhao
author_facet	Heng Zhang Qiang Ju Jing Ji Yanjie Zhao
author_sort	Heng Zhang
title	Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma
title_short	Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma
title_full	Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma
title_fullStr	Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma
title_full_unstemmed	Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma
title_sort	pan-cancer analysis reveals fh as a potential prognostic and immunological biomarker in lung adenocarcinoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d2278ae5af0645878401f4acd53e86f5
work_keys_str_mv	AT hengzhang pancanceranalysisrevealsfhasapotentialprognosticandimmunologicalbiomarkerinlungadenocarcinoma AT qiangju pancanceranalysisrevealsfhasapotentialprognosticandimmunologicalbiomarkerinlungadenocarcinoma AT jingji pancanceranalysisrevealsfhasapotentialprognosticandimmunologicalbiomarkerinlungadenocarcinoma AT yanjiezhao pancanceranalysisrevealsfhasapotentialprognosticandimmunologicalbiomarkerinlungadenocarcinoma
_version_	1718443316074250240

Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma

Ejemplares similares