Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus

ABSTRACT For DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach to study the pathogenicity of a novel human adenovirus with a natural...

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Autores principales:	Christopher M. Robinson, Xiaohong Zhou, Jaya Rajaiya, Mohammad A. Yousuf, Gurdeep Singh, Joshua J. DeSerres, Michael P. Walsh, Sallene Wong, Donald Seto, David W. Dyer, James Chodosh, Morris S. Jones
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d22af2d76bcc4ef7a438eff26d3f60b1
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spelling	oai:doaj.org-article:d22af2d76bcc4ef7a438eff26d3f60b12021-11-15T15:40:28ZPredicting the Next Eye Pathogen: Analysis of a Novel Adenovirus10.1128/mBio.00595-122150-7511https://doaj.org/article/d22af2d76bcc4ef7a438eff26d3f60b12013-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00595-12https://doaj.org/toc/2150-7511ABSTRACT For DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach to study the pathogenicity of a novel human adenovirus with a naturally occurring deletion of the canonical penton base Arg-Gly-Asp (RGD) loop, thought to be critical to cellular entry by adenoviruses. Bioinformatic analysis revealed a new highly recombinant species D human adenovirus (HAdV-D60). A synthesis of in silico and laboratory approaches revealed a potential ocular tropism for the new virus. In vivo, inflammation induced by the virus was dramatically greater than that by adenovirus type 37, a major eye pathogen, possibly due to a novel alternate ligand, Tyr-Gly-Asp (YGD), on the penton base protein. The combination of bioinformatics and laboratory simulation may have important applications in the prediction of tissue tropism for newly discovered and emerging viruses. IMPORTANCE The ongoing dance between a virus and its host distinctly shapes how the virus evolves. While human adenoviruses typically cause mild infections, recent reports have described newly characterized adenoviruses that cause severe, sometimes fatal human infections. Here, we report a systems biology approach to show how evolution has affected the disease potential of a recently identified novel human adenovirus. A comprehensive understanding of viral evolution and pathogenicity is essential to our capacity to foretell the potential impact on human disease for new and emerging viruses.Christopher M. RobinsonXiaohong ZhouJaya RajaiyaMohammad A. YousufGurdeep SinghJoshua J. DeSerresMichael P. WalshSallene WongDonald SetoDavid W. DyerJames ChodoshMorris S. JonesAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 2 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Christopher M. Robinson Xiaohong Zhou Jaya Rajaiya Mohammad A. Yousuf Gurdeep Singh Joshua J. DeSerres Michael P. Walsh Sallene Wong Donald Seto David W. Dyer James Chodosh Morris S. Jones Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus
description	ABSTRACT For DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach to study the pathogenicity of a novel human adenovirus with a naturally occurring deletion of the canonical penton base Arg-Gly-Asp (RGD) loop, thought to be critical to cellular entry by adenoviruses. Bioinformatic analysis revealed a new highly recombinant species D human adenovirus (HAdV-D60). A synthesis of in silico and laboratory approaches revealed a potential ocular tropism for the new virus. In vivo, inflammation induced by the virus was dramatically greater than that by adenovirus type 37, a major eye pathogen, possibly due to a novel alternate ligand, Tyr-Gly-Asp (YGD), on the penton base protein. The combination of bioinformatics and laboratory simulation may have important applications in the prediction of tissue tropism for newly discovered and emerging viruses. IMPORTANCE The ongoing dance between a virus and its host distinctly shapes how the virus evolves. While human adenoviruses typically cause mild infections, recent reports have described newly characterized adenoviruses that cause severe, sometimes fatal human infections. Here, we report a systems biology approach to show how evolution has affected the disease potential of a recently identified novel human adenovirus. A comprehensive understanding of viral evolution and pathogenicity is essential to our capacity to foretell the potential impact on human disease for new and emerging viruses.
format	article
author	Christopher M. Robinson Xiaohong Zhou Jaya Rajaiya Mohammad A. Yousuf Gurdeep Singh Joshua J. DeSerres Michael P. Walsh Sallene Wong Donald Seto David W. Dyer James Chodosh Morris S. Jones
author_facet	Christopher M. Robinson Xiaohong Zhou Jaya Rajaiya Mohammad A. Yousuf Gurdeep Singh Joshua J. DeSerres Michael P. Walsh Sallene Wong Donald Seto David W. Dyer James Chodosh Morris S. Jones
author_sort	Christopher M. Robinson
title	Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus
title_short	Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus
title_full	Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus
title_fullStr	Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus
title_full_unstemmed	Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus
title_sort	predicting the next eye pathogen: analysis of a novel adenovirus
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/d22af2d76bcc4ef7a438eff26d3f60b1
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Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus

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