Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling
Immune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deterioration of cardiac function.
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Nature Portfolio
2021
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oai:doaj.org-article:d22cf22ea4844f0bb37075c442f362fe2021-12-02T13:34:49ZCytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling10.1038/s41467-021-21737-92041-1723https://doaj.org/article/d22cf22ea4844f0bb37075c442f362fe2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21737-9https://doaj.org/toc/2041-1723Immune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deterioration of cardiac function.Icia Santos-ZasJeremie LemariéIvana ZlatanovaMarine CachanadoJean-Christophe SeghezziHakim BenamerPascal GoubeMarie VandestienneRaphael CohenMaya EzzoVincent DuvalYujiao ZhangJin-Bo SuAlain BizéLucien SambinPhilippe BonninMaxime BranchereauChristophe HeymesCorinne TanchotJosé VilarClement DelacroixJean-Sebastien HulotClement CochainPatrick BrunevalNicolas DanchinAlain TedguiZiad MallatTabassome SimonBijan GhalehJean-Sébastien SilvestreHafid Ait-OufellaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Icia Santos-Zas Jeremie Lemarié Ivana Zlatanova Marine Cachanado Jean-Christophe Seghezzi Hakim Benamer Pascal Goube Marie Vandestienne Raphael Cohen Maya Ezzo Vincent Duval Yujiao Zhang Jin-Bo Su Alain Bizé Lucien Sambin Philippe Bonnin Maxime Branchereau Christophe Heymes Corinne Tanchot José Vilar Clement Delacroix Jean-Sebastien Hulot Clement Cochain Patrick Bruneval Nicolas Danchin Alain Tedgui Ziad Mallat Tabassome Simon Bijan Ghaleh Jean-Sébastien Silvestre Hafid Ait-Oufella Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| description |
Immune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deterioration of cardiac function. |
| format |
article |
| author |
Icia Santos-Zas Jeremie Lemarié Ivana Zlatanova Marine Cachanado Jean-Christophe Seghezzi Hakim Benamer Pascal Goube Marie Vandestienne Raphael Cohen Maya Ezzo Vincent Duval Yujiao Zhang Jin-Bo Su Alain Bizé Lucien Sambin Philippe Bonnin Maxime Branchereau Christophe Heymes Corinne Tanchot José Vilar Clement Delacroix Jean-Sebastien Hulot Clement Cochain Patrick Bruneval Nicolas Danchin Alain Tedgui Ziad Mallat Tabassome Simon Bijan Ghaleh Jean-Sébastien Silvestre Hafid Ait-Oufella |
| author_facet |
Icia Santos-Zas Jeremie Lemarié Ivana Zlatanova Marine Cachanado Jean-Christophe Seghezzi Hakim Benamer Pascal Goube Marie Vandestienne Raphael Cohen Maya Ezzo Vincent Duval Yujiao Zhang Jin-Bo Su Alain Bizé Lucien Sambin Philippe Bonnin Maxime Branchereau Christophe Heymes Corinne Tanchot José Vilar Clement Delacroix Jean-Sebastien Hulot Clement Cochain Patrick Bruneval Nicolas Danchin Alain Tedgui Ziad Mallat Tabassome Simon Bijan Ghaleh Jean-Sébastien Silvestre Hafid Ait-Oufella |
| author_sort |
Icia Santos-Zas |
| title |
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_short |
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_full |
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_fullStr |
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_full_unstemmed |
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_sort |
cytotoxic cd8+ t cells promote granzyme b-dependent adverse post-ischemic cardiac remodeling |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d22cf22ea4844f0bb37075c442f362fe |
| work_keys_str_mv |
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