Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study

Abstract Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a population-based setting. Data from the prospective Nord-Trøndelag Healt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S. Rostami, M. Hoff, H. Dalen, K. Hveem, V. Videm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d22e3ec2d9c1437ab94724a67bcfe4b6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d22e3ec2d9c1437ab94724a67bcfe4b6
record_format	dspace
spelling	oai:doaj.org-article:d22e3ec2d9c1437ab94724a67bcfe4b62021-12-02T12:33:53ZGenetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study10.1038/s41598-020-77432-02045-2322https://doaj.org/article/d22e3ec2d9c1437ab94724a67bcfe4b62020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77432-0https://doaj.org/toc/2045-2322Abstract Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a population-based setting. Data from the prospective Nord-Trøndelag Health Study (HUNT2: 1995–1997 and HUNT3: 2006–2008) were used. wGRS added each participant’s carriage of all risk variants weighted by the coefficient from published association studies. Published wGRS for CAD and RA were analysed in Cox regression with MI as outcome, age as analysis time, and censoring at the first MI, death, or 31.12.2017. 2609 of 61,465 participants developed MI during follow-up (mean 17.7 years). The best-fitting wGRS for CAD and RA included 157 and 27 single-nucleotide polymorphisms, respectively. In multivariable analysis including traditional CAD risk factors, the CAD wGRS was associated with MI [hazard ratio = 1.23 (95% CI 1.18–1.27) for each SD increase, p < 0.0001] in RA patients (n = 433) and controls. The RA wGRS was not significant (p = 0.06). Independently from traditional risk factors, a CAD wGRS was significantly associated with the risk for MI in RA patients and controls, whereas an RA wGRS was not. The captured genetic risk for RA contributed little to the risk of MI.S. RostamiM. HoffH. DalenK. HveemV. VidemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. Rostami M. Hoff H. Dalen K. Hveem V. Videm Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
description	Abstract Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a population-based setting. Data from the prospective Nord-Trøndelag Health Study (HUNT2: 1995–1997 and HUNT3: 2006–2008) were used. wGRS added each participant’s carriage of all risk variants weighted by the coefficient from published association studies. Published wGRS for CAD and RA were analysed in Cox regression with MI as outcome, age as analysis time, and censoring at the first MI, death, or 31.12.2017. 2609 of 61,465 participants developed MI during follow-up (mean 17.7 years). The best-fitting wGRS for CAD and RA included 157 and 27 single-nucleotide polymorphisms, respectively. In multivariable analysis including traditional CAD risk factors, the CAD wGRS was associated with MI [hazard ratio = 1.23 (95% CI 1.18–1.27) for each SD increase, p < 0.0001] in RA patients (n = 433) and controls. The RA wGRS was not significant (p = 0.06). Independently from traditional risk factors, a CAD wGRS was significantly associated with the risk for MI in RA patients and controls, whereas an RA wGRS was not. The captured genetic risk for RA contributed little to the risk of MI.
format	article
author	S. Rostami M. Hoff H. Dalen K. Hveem V. Videm
author_facet	S. Rostami M. Hoff H. Dalen K. Hveem V. Videm
author_sort	S. Rostami
title	Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
title_short	Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
title_full	Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
title_fullStr	Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
title_full_unstemmed	Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
title_sort	genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based hunt study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d22e3ec2d9c1437ab94724a67bcfe4b6
work_keys_str_mv	AT srostami geneticriskscoreassociationsformyocardialinfarctionarecomparableinpersonswithandwithoutrheumatoidarthritisthepopulationbasedhuntstudy AT mhoff geneticriskscoreassociationsformyocardialinfarctionarecomparableinpersonswithandwithoutrheumatoidarthritisthepopulationbasedhuntstudy AT hdalen geneticriskscoreassociationsformyocardialinfarctionarecomparableinpersonswithandwithoutrheumatoidarthritisthepopulationbasedhuntstudy AT khveem geneticriskscoreassociationsformyocardialinfarctionarecomparableinpersonswithandwithoutrheumatoidarthritisthepopulationbasedhuntstudy AT vvidem geneticriskscoreassociationsformyocardialinfarctionarecomparableinpersonswithandwithoutrheumatoidarthritisthepopulationbasedhuntstudy
_version_	1718393887093948416

Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study

Ejemplares similares