The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass
Abstract The change in gut microbiota is an important mechanism of the amelioration of type 2 diabetes mellitus (T2DM) after bariatric surgery. Here, we observe that the modified jejunoileal bypass effectively decreases body weight gain, fasting blood glucose, and lipids level in serum; additionally...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d24326a788334a70af9c6f6e98fe8e7d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d24326a788334a70af9c6f6e98fe8e7d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d24326a788334a70af9c6f6e98fe8e7d2021-12-02T13:20:23ZThe role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass10.1038/s41598-021-84355-x2045-2322https://doaj.org/article/d24326a788334a70af9c6f6e98fe8e7d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84355-xhttps://doaj.org/toc/2045-2322Abstract The change in gut microbiota is an important mechanism of the amelioration of type 2 diabetes mellitus (T2DM) after bariatric surgery. Here, we observe that the modified jejunoileal bypass effectively decreases body weight gain, fasting blood glucose, and lipids level in serum; additionally, islet β-cell function, glucose tolerance, and insulin resistance were markedly ameliorated. The hypoglycemic effect and the improvement in islet β-cell function depend on the changes in gut microbiota structure. modified jejunoileal bypass increases the abundance of gut Escherichia coli and Ruminococcus gnavus and the levels of serum glycine, histidine, and glutamine in T2DM rats; and decreases the abundance of Prevotella copri and the levels of serum branched chain amino acids, which are significantly related to the improvement of islet β-cell function in T2DM rats. Our results suggest that amino acid metabolism may contribute to the islet β-cell function in T2DM rats after modified jejunoileal bypass and that improving gut microbiota composition is a potential therapeutic strategy for T2DM.Cai TanZhihua ZhengXiaogang WanJiaqing CaoRan WeiJinyuan DuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Cai Tan Zhihua Zheng Xiaogang Wan Jiaqing Cao Ran Wei Jinyuan Duan The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass |
| description |
Abstract The change in gut microbiota is an important mechanism of the amelioration of type 2 diabetes mellitus (T2DM) after bariatric surgery. Here, we observe that the modified jejunoileal bypass effectively decreases body weight gain, fasting blood glucose, and lipids level in serum; additionally, islet β-cell function, glucose tolerance, and insulin resistance were markedly ameliorated. The hypoglycemic effect and the improvement in islet β-cell function depend on the changes in gut microbiota structure. modified jejunoileal bypass increases the abundance of gut Escherichia coli and Ruminococcus gnavus and the levels of serum glycine, histidine, and glutamine in T2DM rats; and decreases the abundance of Prevotella copri and the levels of serum branched chain amino acids, which are significantly related to the improvement of islet β-cell function in T2DM rats. Our results suggest that amino acid metabolism may contribute to the islet β-cell function in T2DM rats after modified jejunoileal bypass and that improving gut microbiota composition is a potential therapeutic strategy for T2DM. |
| format |
article |
| author |
Cai Tan Zhihua Zheng Xiaogang Wan Jiaqing Cao Ran Wei Jinyuan Duan |
| author_facet |
Cai Tan Zhihua Zheng Xiaogang Wan Jiaqing Cao Ran Wei Jinyuan Duan |
| author_sort |
Cai Tan |
| title |
The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass |
| title_short |
The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass |
| title_full |
The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass |
| title_fullStr |
The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass |
| title_full_unstemmed |
The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass |
| title_sort |
role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d24326a788334a70af9c6f6e98fe8e7d |
| work_keys_str_mv |
AT caitan theroleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT zhihuazheng theroleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT xiaogangwan theroleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT jiaqingcao theroleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT ranwei theroleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT jinyuanduan theroleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT caitan roleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT zhihuazheng roleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT xiaogangwan roleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT jiaqingcao roleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT ranwei roleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass AT jinyuanduan roleofgutmicrobiotaandaminometabolismintheeffectsofimprovementofisletbcellfunctionaftermodifiedjejunoilealbypass |
| _version_ |
1718393240524161024 |