Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study

Xiuting Huang,1,* Xiuying Zhang,1,* Xianghai Zhou,1 Xueyao Han,1 Zuodi Fu,2 Yufeng Li,2 Linong Ji1 1Department of Endocrinology and Metabolism, Peking University People’s Hospital, Peking University Diabetes Center, Beijing 100044, People’s Republic of China; 2Department of Endoc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huang X, Zhang X, Zhou X, Han X, Fu Z, Li Y, Ji L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	type 2 diabetes pre-diabetes thyroid dysfunction epidemiology Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d2469986a53644cd986c561603a167b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d2469986a53644cd986c561603a167b2
record_format	dspace
spelling	oai:doaj.org-article:d2469986a53644cd986c561603a167b22021-12-02T11:12:54ZPrevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study1178-7007https://doaj.org/article/d2469986a53644cd986c561603a167b22020-11-01T00:00:00Zhttps://www.dovepress.com/prevalence-of-thyroid-dysfunction-in-a-chinese-population-with-differe-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xiuting Huang,1,* Xiuying Zhang,1,* Xianghai Zhou,1 Xueyao Han,1 Zuodi Fu,2 Yufeng Li,2 Linong Ji1 1Department of Endocrinology and Metabolism, Peking University People’s Hospital, Peking University Diabetes Center, Beijing 100044, People’s Republic of China; 2Department of Endocrinology and Metabolism, Capital Medical University Pinggu Teaching Hospital, Beijing 101200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yufeng LiDepartment of Endocrinology and Metabolism, Capital Medical University Pinggu Teaching Hospital, No. 59, Xinping North Street, Pinggu District, Beijing 101200, People’s Republic of ChinaTel/Fax +86 10 89978790Email doctorlyf@126.comLinong JiDepartment of Endocrinology and Metabolism, Peking University People’s Hospital, Peking University Diabetes Center, No. 11, Xizhimen South Street, Xicheng District, Beijing 100044, People’s Republic of ChinaTel +86 10 88324108Fax +86 10 88325534Email jilinong@gmail.comAim: Impaired glucose metabolism and thyroid dysfunction (TD) are the two most common chronic metabolic disorders. This study aimed to investigate the epidemiological characteristics of TD in different status of glucose tolerance in a community-based Chinese population and to understand the association between TD and glucose metabolism.Methods: A community-based population study of metabolic disease was conducted from June 2013 to September 2014 in Beijing, China. Residents aged 26– 76 years were selected according to gender and age composition using multi-stage stratified random sampling process. All participants underwent serum thyroid function and thyroid-associated antibody tests. The status of glucose tolerance was determined using 75g-oral glucose tolerance test. Chi-square test was used to compare the differences in prevalence. Multivariate logistic regression analysis was used to determine the impact of insulin resistance (IR) on thyroid function.Results: By analyzing 3986 participants who were included in the survey, the prevalence of type 2 diabetes (T2DM) and pre-diabetes (pre-DM) was 18.59% and 26.79%, respectively. The prevalence of TD was 8.81%, with overt hyperthyroidism accounting for 0.38%; subclinical hyperthyroidism, 1.86%; overt hypothyroidism, 0.70%; and subclinical hypothyroidism, 5.87%. The prevalence of TD increased with gradually deteriorated glucose tolerance (7.63% in those with normal glucose tolerance, 9.27% in pre-DM, and 11.61% in T2DM) in both men and women. Each unit of higher HOMA-IR was associated with 7% higher likelihood of having subclinical hypothyroidism.Conclusion: The coexisting of TD with T2DM and pre-DM is high in this community-based Chinese population, suggesting a close relationship between TD and glucose metabolism.Keywords: type 2 diabetes, pre-diabetes, thyroid dysfunction, epidemiologyHuang XZhang XZhou XHan XFu ZLi YJi LDove Medical Pressarticletype 2 diabetespre-diabetesthyroid dysfunctionepidemiologySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4361-4368 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes pre-diabetes thyroid dysfunction epidemiology Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes pre-diabetes thyroid dysfunction epidemiology Specialties of internal medicine RC581-951 Huang X Zhang X Zhou X Han X Fu Z Li Y Ji L Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study
description	Xiuting Huang,1,* Xiuying Zhang,1,* Xianghai Zhou,1 Xueyao Han,1 Zuodi Fu,2 Yufeng Li,2 Linong Ji1 1Department of Endocrinology and Metabolism, Peking University People’s Hospital, Peking University Diabetes Center, Beijing 100044, People’s Republic of China; 2Department of Endocrinology and Metabolism, Capital Medical University Pinggu Teaching Hospital, Beijing 101200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yufeng LiDepartment of Endocrinology and Metabolism, Capital Medical University Pinggu Teaching Hospital, No. 59, Xinping North Street, Pinggu District, Beijing 101200, People’s Republic of ChinaTel/Fax +86 10 89978790Email doctorlyf@126.comLinong JiDepartment of Endocrinology and Metabolism, Peking University People’s Hospital, Peking University Diabetes Center, No. 11, Xizhimen South Street, Xicheng District, Beijing 100044, People’s Republic of ChinaTel +86 10 88324108Fax +86 10 88325534Email jilinong@gmail.comAim: Impaired glucose metabolism and thyroid dysfunction (TD) are the two most common chronic metabolic disorders. This study aimed to investigate the epidemiological characteristics of TD in different status of glucose tolerance in a community-based Chinese population and to understand the association between TD and glucose metabolism.Methods: A community-based population study of metabolic disease was conducted from June 2013 to September 2014 in Beijing, China. Residents aged 26– 76 years were selected according to gender and age composition using multi-stage stratified random sampling process. All participants underwent serum thyroid function and thyroid-associated antibody tests. The status of glucose tolerance was determined using 75g-oral glucose tolerance test. Chi-square test was used to compare the differences in prevalence. Multivariate logistic regression analysis was used to determine the impact of insulin resistance (IR) on thyroid function.Results: By analyzing 3986 participants who were included in the survey, the prevalence of type 2 diabetes (T2DM) and pre-diabetes (pre-DM) was 18.59% and 26.79%, respectively. The prevalence of TD was 8.81%, with overt hyperthyroidism accounting for 0.38%; subclinical hyperthyroidism, 1.86%; overt hypothyroidism, 0.70%; and subclinical hypothyroidism, 5.87%. The prevalence of TD increased with gradually deteriorated glucose tolerance (7.63% in those with normal glucose tolerance, 9.27% in pre-DM, and 11.61% in T2DM) in both men and women. Each unit of higher HOMA-IR was associated with 7% higher likelihood of having subclinical hypothyroidism.Conclusion: The coexisting of TD with T2DM and pre-DM is high in this community-based Chinese population, suggesting a close relationship between TD and glucose metabolism.Keywords: type 2 diabetes, pre-diabetes, thyroid dysfunction, epidemiology
format	article
author	Huang X Zhang X Zhou X Han X Fu Z Li Y Ji L
author_facet	Huang X Zhang X Zhou X Han X Fu Z Li Y Ji L
author_sort	Huang X
title	Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study
title_short	Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study
title_full	Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study
title_fullStr	Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study
title_full_unstemmed	Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study
title_sort	prevalence of thyroid dysfunction in a chinese population with different glucose intolerance status: a community-based cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d2469986a53644cd986c561603a167b2
work_keys_str_mv	AT huangx prevalenceofthyroiddysfunctioninachinesepopulationwithdifferentglucoseintolerancestatusacommunitybasedcrosssectionalstudy AT zhangx prevalenceofthyroiddysfunctioninachinesepopulationwithdifferentglucoseintolerancestatusacommunitybasedcrosssectionalstudy AT zhoux prevalenceofthyroiddysfunctioninachinesepopulationwithdifferentglucoseintolerancestatusacommunitybasedcrosssectionalstudy AT hanx prevalenceofthyroiddysfunctioninachinesepopulationwithdifferentglucoseintolerancestatusacommunitybasedcrosssectionalstudy AT fuz prevalenceofthyroiddysfunctioninachinesepopulationwithdifferentglucoseintolerancestatusacommunitybasedcrosssectionalstudy AT liy prevalenceofthyroiddysfunctioninachinesepopulationwithdifferentglucoseintolerancestatusacommunitybasedcrosssectionalstudy AT jil prevalenceofthyroiddysfunctioninachinesepopulationwithdifferentglucoseintolerancestatusacommunitybasedcrosssectionalstudy
_version_	1718396139340824576

Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study

Ejemplares similares