Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection

Long-acting formulation of the integrase inhibitor cabotegravir (CAB LA) is in clinical development for HIV pre-exposure prophylaxis (PrEP). Here, using a SHIV macaque model, the authors show emergence of integrase mutations associated to CAB LA PrEP that confer pan-integrase inhibitor resistance.

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Autores principales:	Jessica Radzio-Basu, Olivia Council, Mian-er Cong, Susan Ruone, Alicia Newton, Xierong Wei, James Mitchell, Shanon Ellis, Christos J. Petropoulos, Wei Huang, William Spreen, Walid Heneine, J. Gerardo García-Lerma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d248393d33e74833a7f91fb2b8224578
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spelling	oai:doaj.org-article:d248393d33e74833a7f91fb2b82245782021-12-02T14:38:43ZDrug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection10.1038/s41467-019-10047-w2041-1723https://doaj.org/article/d248393d33e74833a7f91fb2b82245782019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10047-whttps://doaj.org/toc/2041-1723Long-acting formulation of the integrase inhibitor cabotegravir (CAB LA) is in clinical development for HIV pre-exposure prophylaxis (PrEP). Here, using a SHIV macaque model, the authors show emergence of integrase mutations associated to CAB LA PrEP that confer pan-integrase inhibitor resistance.Jessica Radzio-BasuOlivia CouncilMian-er CongSusan RuoneAlicia NewtonXierong WeiJames MitchellShanon EllisChristos J. PetropoulosWei HuangWilliam SpreenWalid HeneineJ. Gerardo García-LermaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica Radzio-Basu Olivia Council Mian-er Cong Susan Ruone Alicia Newton Xierong Wei James Mitchell Shanon Ellis Christos J. Petropoulos Wei Huang William Spreen Walid Heneine J. Gerardo García-Lerma Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection
description	Long-acting formulation of the integrase inhibitor cabotegravir (CAB LA) is in clinical development for HIV pre-exposure prophylaxis (PrEP). Here, using a SHIV macaque model, the authors show emergence of integrase mutations associated to CAB LA PrEP that confer pan-integrase inhibitor resistance.
format	article
author	Jessica Radzio-Basu Olivia Council Mian-er Cong Susan Ruone Alicia Newton Xierong Wei James Mitchell Shanon Ellis Christos J. Petropoulos Wei Huang William Spreen Walid Heneine J. Gerardo García-Lerma
author_facet	Jessica Radzio-Basu Olivia Council Mian-er Cong Susan Ruone Alicia Newton Xierong Wei James Mitchell Shanon Ellis Christos J. Petropoulos Wei Huang William Spreen Walid Heneine J. Gerardo García-Lerma
author_sort	Jessica Radzio-Basu
title	Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection
title_short	Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection
title_full	Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection
title_fullStr	Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection
title_full_unstemmed	Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection
title_sort	drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute shiv infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d248393d33e74833a7f91fb2b8224578
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Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection

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