Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy

As an organism ages, many physiological processes change, including the immune system. This process, called immunosenescence, characterized by abnormal activation and imbalance of innate and adaptive immunity, leads to a state of chronic low-grade systemic inflammation, termed inflammaging. Aging an...

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Autores principales:	Slavko Mojsilović, Aleksandra Jauković, Tamara Kukolj, Hristina Obradović, Ivana Okić Đorđević, Anđelija Petrović, Diana Bugarski
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesenchymal stromal/stem cells senescence inflammaging tumor microenvironment Medicine R
Acceso en línea:	https://doaj.org/article/d24aa7be69f74c2ea26bcd2f45486af1
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spelling	oai:doaj.org-article:d24aa7be69f74c2ea26bcd2f45486af12021-11-25T18:07:27ZTumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy10.3390/jpm111111332075-4426https://doaj.org/article/d24aa7be69f74c2ea26bcd2f45486af12021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1133https://doaj.org/toc/2075-4426As an organism ages, many physiological processes change, including the immune system. This process, called immunosenescence, characterized by abnormal activation and imbalance of innate and adaptive immunity, leads to a state of chronic low-grade systemic inflammation, termed inflammaging. Aging and inflammaging are considered to be the root of many diseases of the elderly, as infections, autoimmune and chronic inflammatory diseases, degenerative diseases, and cancer. The role of mesenchymal stromal/stem cells (MSCs) in the inflammaging process and the age-related diseases is not completely established, although numerous features of aging MSCs, including altered immunomodulatory properties, impeded MSC niche supporting functions, and senescent MSC secretory repertoire are consistent with inflammaging development. Although senescence has its physiological function and can represent a mechanism of tumor prevention, in most cases it eventually transforms into a deleterious (para-)inflammatory process that promotes tumor growth. In this review we are going through current literature, trying to explore the role of senescent MSCs in making and/or sustaining a microenvironment permissive to tumor development and to analyze the therapeutic options that could target this process.Slavko MojsilovićAleksandra JaukovićTamara KukoljHristina ObradovićIvana Okić ĐorđevićAnđelija PetrovićDiana BugarskiMDPI AGarticlemesenchymal stromal/stem cellssenescenceinflammagingtumormicroenvironmentMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1133, p 1133 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stromal/stem cells senescence inflammaging tumor microenvironment Medicine R
spellingShingle	mesenchymal stromal/stem cells senescence inflammaging tumor microenvironment Medicine R Slavko Mojsilović Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić Đorđević Anđelija Petrović Diana Bugarski Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
description	As an organism ages, many physiological processes change, including the immune system. This process, called immunosenescence, characterized by abnormal activation and imbalance of innate and adaptive immunity, leads to a state of chronic low-grade systemic inflammation, termed inflammaging. Aging and inflammaging are considered to be the root of many diseases of the elderly, as infections, autoimmune and chronic inflammatory diseases, degenerative diseases, and cancer. The role of mesenchymal stromal/stem cells (MSCs) in the inflammaging process and the age-related diseases is not completely established, although numerous features of aging MSCs, including altered immunomodulatory properties, impeded MSC niche supporting functions, and senescent MSC secretory repertoire are consistent with inflammaging development. Although senescence has its physiological function and can represent a mechanism of tumor prevention, in most cases it eventually transforms into a deleterious (para-)inflammatory process that promotes tumor growth. In this review we are going through current literature, trying to explore the role of senescent MSCs in making and/or sustaining a microenvironment permissive to tumor development and to analyze the therapeutic options that could target this process.
format	article
author	Slavko Mojsilović Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić Đorđević Anđelija Petrović Diana Bugarski
author_facet	Slavko Mojsilović Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić Đorđević Anđelija Petrović Diana Bugarski
author_sort	Slavko Mojsilović
title	Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
title_short	Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
title_full	Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
title_fullStr	Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
title_full_unstemmed	Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
title_sort	tumorigenic aspects of msc senescence—implication in cancer development and therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d24aa7be69f74c2ea26bcd2f45486af1
work_keys_str_mv	AT slavkomojsilovic tumorigenicaspectsofmscsenescenceimplicationincancerdevelopmentandtherapy AT aleksandrajaukovic tumorigenicaspectsofmscsenescenceimplicationincancerdevelopmentandtherapy AT tamarakukolj tumorigenicaspectsofmscsenescenceimplicationincancerdevelopmentandtherapy AT hristinaobradovic tumorigenicaspectsofmscsenescenceimplicationincancerdevelopmentandtherapy AT ivanaokicđorđevic tumorigenicaspectsofmscsenescenceimplicationincancerdevelopmentandtherapy AT anđelijapetrovic tumorigenicaspectsofmscsenescenceimplicationincancerdevelopmentandtherapy AT dianabugarski tumorigenicaspectsofmscsenescenceimplicationincancerdevelopmentandtherapy
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Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy

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