Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology

The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed. When performing a cytological examination by liquid-based cytology, it...

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Autores principales:	Artem K. Aksamentov, Nadezhda V. Melnikova, Nadezhda A. Kolyshkina, Olga N. Kucherova, Vladimir P. Baklaushev
Formato:	article
Lenguaje:	RU
Publicado:	Eco-vector 2021
Materias:	pap-test screening cervical cancer mirna mrna liquid-based cytology dna methylation Medicine R
Acceso en línea:	https://doaj.org/article/d24bf8e2667b41de82f65687df9e9e6e
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id	oai:doaj.org-article:d24bf8e2667b41de82f65687df9e9e6e
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spelling	oai:doaj.org-article:d24bf8e2667b41de82f65687df9e9e6e2021-11-30T18:15:21ZAdditional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology2220-30952618-862710.17816/clinpract64982https://doaj.org/article/d24bf8e2667b41de82f65687df9e9e6e2021-03-01T00:00:00Zhttps://journals.eco-vector.com/clinpractice/article/viewFile/64982/pdfhttps://doaj.org/toc/2220-3095https://doaj.org/toc/2618-8627The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed. When performing a cytological examination by liquid-based cytology, it is possible to conduct additional diagnostic studies that can be used to more effectively sort patients in order to optimize the volume of diagnostic and therapeutic measures. The article highlights the possibilities of diagnostic tests based on the assessment of microRNA and mRNA expression, as well as tests based on the analysis of DNA methylation from the cytological material. The introduction of new molecular genetic predictors of the cervical cancer development into clinical practice can increase the effectiveness of currently used screening programs.Artem K. AksamentovNadezhda V. MelnikovaNadezhda A. KolyshkinaOlga N. KucherovaVladimir P. BaklaushevEco-vectorarticlepap-testscreeningcervical cancermirnamrnaliquid-based cytologydna methylationMedicineRRUКлиническая практика , Vol 12, Iss 1, Pp 82-89 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	pap-test screening cervical cancer mirna mrna liquid-based cytology dna methylation Medicine R
spellingShingle	pap-test screening cervical cancer mirna mrna liquid-based cytology dna methylation Medicine R Artem K. Aksamentov Nadezhda V. Melnikova Nadezhda A. Kolyshkina Olga N. Kucherova Vladimir P. Baklaushev Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
description	The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed. When performing a cytological examination by liquid-based cytology, it is possible to conduct additional diagnostic studies that can be used to more effectively sort patients in order to optimize the volume of diagnostic and therapeutic measures. The article highlights the possibilities of diagnostic tests based on the assessment of microRNA and mRNA expression, as well as tests based on the analysis of DNA methylation from the cytological material. The introduction of new molecular genetic predictors of the cervical cancer development into clinical practice can increase the effectiveness of currently used screening programs.
format	article
author	Artem K. Aksamentov Nadezhda V. Melnikova Nadezhda A. Kolyshkina Olga N. Kucherova Vladimir P. Baklaushev
author_facet	Artem K. Aksamentov Nadezhda V. Melnikova Nadezhda A. Kolyshkina Olga N. Kucherova Vladimir P. Baklaushev
author_sort	Artem K. Aksamentov
title	Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
title_short	Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
title_full	Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
title_fullStr	Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
title_full_unstemmed	Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
title_sort	additional diagnostic capabilities in the practice of a pap-test using liquid-based cytology
publisher	Eco-vector
publishDate	2021
url	https://doaj.org/article/d24bf8e2667b41de82f65687df9e9e6e
work_keys_str_mv	AT artemkaksamentov additionaldiagnosticcapabilitiesinthepracticeofapaptestusingliquidbasedcytology AT nadezhdavmelnikova additionaldiagnosticcapabilitiesinthepracticeofapaptestusingliquidbasedcytology AT nadezhdaakolyshkina additionaldiagnosticcapabilitiesinthepracticeofapaptestusingliquidbasedcytology AT olgankucherova additionaldiagnosticcapabilitiesinthepracticeofapaptestusingliquidbasedcytology AT vladimirpbaklaushev additionaldiagnosticcapabilitiesinthepracticeofapaptestusingliquidbasedcytology
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Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology

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