Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.

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Autores principales:	Giulia Della Chiara, Federica Gervasoni, Michaela Fakiola, Chiara Godano, Claudia D’Oria, Luca Azzolin, Raoul Jean Pierre Bonnal, Giulia Moreni, Lorenzo Drufuca, Grazisa Rossetti, Valeria Ranzani, Ramona Bason, Marco De Simone, Francesco Panariello, Ivan Ferrari, Tanya Fabbris, Francesca Zanconato, Mattia Forcato, Oriana Romano, Jimmy Caroli, Paola Gruarin, Maria Lucia Sarnicola, Michelangelo Cordenonsi, Alberto Bardelli, Nicola Zucchini, Andrea Pisani Ceretti, Nicolò Maria Mariani, Andrea Cassingena, Andrea Sartore-Bianchi, Giuseppe Testa, Luca Gianotti, Enrico Opocher, Federica Pisati, Claudio Tripodo, Giuseppe Macino, Salvatore Siena, Silvio Bicciato, Stefano Piccolo, Massimiliano Pagani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d24dcbd0a4754b4e8fdf6d5dd0925565
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d24dcbd0a4754b4e8fdf6d5dd09255652021-12-02T16:45:10ZEpigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ10.1038/s41467-021-22544-y2041-1723https://doaj.org/article/d24dcbd0a4754b4e8fdf6d5dd09255652021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22544-yhttps://doaj.org/toc/2041-1723The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.Giulia Della ChiaraFederica GervasoniMichaela FakiolaChiara GodanoClaudia D’OriaLuca AzzolinRaoul Jean Pierre BonnalGiulia MoreniLorenzo DrufucaGrazisa RossettiValeria RanzaniRamona BasonMarco De SimoneFrancesco PanarielloIvan FerrariTanya FabbrisFrancesca ZanconatoMattia ForcatoOriana RomanoJimmy CaroliPaola GruarinMaria Lucia SarnicolaMichelangelo CordenonsiAlberto BardelliNicola ZucchiniAndrea Pisani CerettiNicolò Maria MarianiAndrea CassingenaAndrea Sartore-BianchiGiuseppe TestaLuca GianottiEnrico OpocherFederica PisatiClaudio TripodoGiuseppe MacinoSalvatore SienaSilvio BicciatoStefano PiccoloMassimiliano PaganiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Della Chiara Federica Gervasoni Michaela Fakiola Chiara Godano Claudia D’Oria Luca Azzolin Raoul Jean Pierre Bonnal Giulia Moreni Lorenzo Drufuca Grazisa Rossetti Valeria Ranzani Ramona Bason Marco De Simone Francesco Panariello Ivan Ferrari Tanya Fabbris Francesca Zanconato Mattia Forcato Oriana Romano Jimmy Caroli Paola Gruarin Maria Lucia Sarnicola Michelangelo Cordenonsi Alberto Bardelli Nicola Zucchini Andrea Pisani Ceretti Nicolò Maria Mariani Andrea Cassingena Andrea Sartore-Bianchi Giuseppe Testa Luca Gianotti Enrico Opocher Federica Pisati Claudio Tripodo Giuseppe Macino Salvatore Siena Silvio Bicciato Stefano Piccolo Massimiliano Pagani Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
description	The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.
format	article
author	Giulia Della Chiara Federica Gervasoni Michaela Fakiola Chiara Godano Claudia D’Oria Luca Azzolin Raoul Jean Pierre Bonnal Giulia Moreni Lorenzo Drufuca Grazisa Rossetti Valeria Ranzani Ramona Bason Marco De Simone Francesco Panariello Ivan Ferrari Tanya Fabbris Francesca Zanconato Mattia Forcato Oriana Romano Jimmy Caroli Paola Gruarin Maria Lucia Sarnicola Michelangelo Cordenonsi Alberto Bardelli Nicola Zucchini Andrea Pisani Ceretti Nicolò Maria Mariani Andrea Cassingena Andrea Sartore-Bianchi Giuseppe Testa Luca Gianotti Enrico Opocher Federica Pisati Claudio Tripodo Giuseppe Macino Salvatore Siena Silvio Bicciato Stefano Piccolo Massimiliano Pagani
author_facet	Giulia Della Chiara Federica Gervasoni Michaela Fakiola Chiara Godano Claudia D’Oria Luca Azzolin Raoul Jean Pierre Bonnal Giulia Moreni Lorenzo Drufuca Grazisa Rossetti Valeria Ranzani Ramona Bason Marco De Simone Francesco Panariello Ivan Ferrari Tanya Fabbris Francesca Zanconato Mattia Forcato Oriana Romano Jimmy Caroli Paola Gruarin Maria Lucia Sarnicola Michelangelo Cordenonsi Alberto Bardelli Nicola Zucchini Andrea Pisani Ceretti Nicolò Maria Mariani Andrea Cassingena Andrea Sartore-Bianchi Giuseppe Testa Luca Gianotti Enrico Opocher Federica Pisati Claudio Tripodo Giuseppe Macino Salvatore Siena Silvio Bicciato Stefano Piccolo Massimiliano Pagani
author_sort	Giulia Della Chiara
title	Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
title_short	Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
title_full	Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
title_fullStr	Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
title_full_unstemmed	Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
title_sort	epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by yap/taz
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d24dcbd0a4754b4e8fdf6d5dd0925565
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Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

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