Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.

<h4>Background and purpose</h4>Anti-inflammatory cytokine and its genetic variations may play an important role in the process of atherosclerosis. We assessed whether serum interleukin-10 (IL-10) and its genetic variations are associated with ischemic stroke in a Chinese general populati...

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Autores principales:	Gaoqiang Xie, Phyo Kyaw Myint, M Justin S Zaman, Ying Li, Liancheng Zhao, Ping Shi, Fuxiu Ren, Yangfeng Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d257ae29bfdf4d8e93df3a42d7693bf2
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spelling	oai:doaj.org-article:d257ae29bfdf4d8e93df3a42d7693bf22021-11-18T08:55:45ZRelationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.1932-620310.1371/journal.pone.0074126https://doaj.org/article/d257ae29bfdf4d8e93df3a42d7693bf22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040186/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and purpose</h4>Anti-inflammatory cytokine and its genetic variations may play an important role in the process of atherosclerosis. We assessed whether serum interleukin-10 (IL-10) and its genetic variations are associated with ischemic stroke in a Chinese general population.<h4>Methods</h4>An epidemiological survey on cardiovascular diseases and their risk factors was carried in a general population in Beijing in 2005. Serum IL-10, IL-6, p-selectin, soluble intercellular adhesion molecule-1 and C-reactive protein were analyzed using ELISA kits, while three IL-10 Single Nucleotide Polymorphisms (SNP) (rs1800872, rs1554286 and rs3021094) were genotyped in 1475 participants.<h4>Results</h4>A high serum IL-10 (top tertile) was significantly associated with ischemic stroke (multivariable adjusted odds ratio (OR) =0.50; 95%CI 0.31-0.81). Rs1800872 (AA vs. AC+CC genotype, OR=1.60; 1.06-2.39), rs1554286(TT vs. CT+CC genotype, OR=1.59; 1.06-2.39), and rs3021094 (CC/CA vs. AA genotype, OR=1.64; 1.04-2.60) were all significantly associated with ischemic stroke even after controlling for age, sex, smoking, systolic blood pressure, total cholesterol, glucose, body mass index and serum IL-10. The SNP score (a summary index of these SNPs) and IL-10 (top tertile) together significantly improved the discriminative power in predicting ischemic stroke by 3.3% (95%CI: 0.2-6.4, p=0.0398) compared to predictions based on conventional risk factors alone.<h4>Conclusions</h4>The lower serum IL-10 concentration and its selected genetic variations were significantly associated with an increased likelihood of ischemic stroke in this cross-sectional study. Our results suggest that more prospective studies should be conducted to provide stronger evidence justifying the use of IL-10 and its SNPs as new biomarkers to identify a predisposition towards ischemic stroke.Gaoqiang XiePhyo Kyaw MyintM Justin S ZamanYing LiLiancheng ZhaoPing ShiFuxiu RenYangfeng WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74126 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gaoqiang Xie Phyo Kyaw Myint M Justin S Zaman Ying Li Liancheng Zhao Ping Shi Fuxiu Ren Yangfeng Wu Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.
description	<h4>Background and purpose</h4>Anti-inflammatory cytokine and its genetic variations may play an important role in the process of atherosclerosis. We assessed whether serum interleukin-10 (IL-10) and its genetic variations are associated with ischemic stroke in a Chinese general population.<h4>Methods</h4>An epidemiological survey on cardiovascular diseases and their risk factors was carried in a general population in Beijing in 2005. Serum IL-10, IL-6, p-selectin, soluble intercellular adhesion molecule-1 and C-reactive protein were analyzed using ELISA kits, while three IL-10 Single Nucleotide Polymorphisms (SNP) (rs1800872, rs1554286 and rs3021094) were genotyped in 1475 participants.<h4>Results</h4>A high serum IL-10 (top tertile) was significantly associated with ischemic stroke (multivariable adjusted odds ratio (OR) =0.50; 95%CI 0.31-0.81). Rs1800872 (AA vs. AC+CC genotype, OR=1.60; 1.06-2.39), rs1554286(TT vs. CT+CC genotype, OR=1.59; 1.06-2.39), and rs3021094 (CC/CA vs. AA genotype, OR=1.64; 1.04-2.60) were all significantly associated with ischemic stroke even after controlling for age, sex, smoking, systolic blood pressure, total cholesterol, glucose, body mass index and serum IL-10. The SNP score (a summary index of these SNPs) and IL-10 (top tertile) together significantly improved the discriminative power in predicting ischemic stroke by 3.3% (95%CI: 0.2-6.4, p=0.0398) compared to predictions based on conventional risk factors alone.<h4>Conclusions</h4>The lower serum IL-10 concentration and its selected genetic variations were significantly associated with an increased likelihood of ischemic stroke in this cross-sectional study. Our results suggest that more prospective studies should be conducted to provide stronger evidence justifying the use of IL-10 and its SNPs as new biomarkers to identify a predisposition towards ischemic stroke.
format	article
author	Gaoqiang Xie Phyo Kyaw Myint M Justin S Zaman Ying Li Liancheng Zhao Ping Shi Fuxiu Ren Yangfeng Wu
author_facet	Gaoqiang Xie Phyo Kyaw Myint M Justin S Zaman Ying Li Liancheng Zhao Ping Shi Fuxiu Ren Yangfeng Wu
author_sort	Gaoqiang Xie
title	Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.
title_short	Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.
title_full	Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.
title_fullStr	Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.
title_full_unstemmed	Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.
title_sort	relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a chinese general population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d257ae29bfdf4d8e93df3a42d7693bf2
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Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.

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