Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors

Abstract To evaluate the role of conventional contrast-enhanced CT (CECT) imaging and dual-energy spectral CT (DECT) perfusion imaging in differentiating the WHO histological subtypes of thymic epithelial tumours (TETs). Eighty-eight patients with TETs who underwent DECT perfusion scans (n = 51) and...

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Autores principales:	Chunhai Yu, Ting Li, Ruiping Zhang, Xiaotang Yang, Zhao Yang, Lei Xin, Zhikai Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d257ff1a088e4e45b74cec7c263b58b2
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spelling	oai:doaj.org-article:d257ff1a088e4e45b74cec7c263b58b22021-12-02T17:04:08ZDual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors10.1038/s41598-020-62466-12045-2322https://doaj.org/article/d257ff1a088e4e45b74cec7c263b58b22020-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-62466-1https://doaj.org/toc/2045-2322Abstract To evaluate the role of conventional contrast-enhanced CT (CECT) imaging and dual-energy spectral CT (DECT) perfusion imaging in differentiating the WHO histological subtypes of thymic epithelial tumours (TETs). Eighty-eight patients with TETs who underwent DECT perfusion scans (n = 51) and conventional CT enhancement scans (n = 37) using a GE Discovery CT750 HD scanner were enrolled in this study. The mean maximal contrast-enhanced range (mean CEmax) and the perfusion and spectral parameters of the lesions were analysed. Among the six WHO subtypes (Type A, AB, B1, B2, and B3 thymoma and thymic carcinoma), the mean CEmax values and most of the perfusion and spectral parameter values of Type A and Type AB were significantly higher than those of the other subtypes (all P < 0.05), and there was no difference among Type B1, B2 and B3 (all P > 0.05). The mean CEmax value was not different between Type B (including Type B1, B2, and B3) and thymic carcinoma (P = 1.000). The PS, IC, NIC and λHU values in the optimal venous phase of thymic carcinoma were higher than those of Type B (all P < 0.05). The parameters of conventional CECT imaging and DECT perfusion imaging can help identify the subtype of TETs, especially those of DECT perfusion imaging in type B thymomas and thymic carcinomas.Chunhai YuTing LiRuiping ZhangXiaotang YangZhao YangLei XinZhikai ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chunhai Yu Ting Li Ruiping Zhang Xiaotang Yang Zhao Yang Lei Xin Zhikai Zhao Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors
description	Abstract To evaluate the role of conventional contrast-enhanced CT (CECT) imaging and dual-energy spectral CT (DECT) perfusion imaging in differentiating the WHO histological subtypes of thymic epithelial tumours (TETs). Eighty-eight patients with TETs who underwent DECT perfusion scans (n = 51) and conventional CT enhancement scans (n = 37) using a GE Discovery CT750 HD scanner were enrolled in this study. The mean maximal contrast-enhanced range (mean CEmax) and the perfusion and spectral parameters of the lesions were analysed. Among the six WHO subtypes (Type A, AB, B1, B2, and B3 thymoma and thymic carcinoma), the mean CEmax values and most of the perfusion and spectral parameter values of Type A and Type AB were significantly higher than those of the other subtypes (all P < 0.05), and there was no difference among Type B1, B2 and B3 (all P > 0.05). The mean CEmax value was not different between Type B (including Type B1, B2, and B3) and thymic carcinoma (P = 1.000). The PS, IC, NIC and λHU values in the optimal venous phase of thymic carcinoma were higher than those of Type B (all P < 0.05). The parameters of conventional CECT imaging and DECT perfusion imaging can help identify the subtype of TETs, especially those of DECT perfusion imaging in type B thymomas and thymic carcinomas.
format	article
author	Chunhai Yu Ting Li Ruiping Zhang Xiaotang Yang Zhao Yang Lei Xin Zhikai Zhao
author_facet	Chunhai Yu Ting Li Ruiping Zhang Xiaotang Yang Zhao Yang Lei Xin Zhikai Zhao
author_sort	Chunhai Yu
title	Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors
title_short	Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors
title_full	Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors
title_fullStr	Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors
title_full_unstemmed	Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors
title_sort	dual-energy ct perfusion imaging for differentiating who subtypes of thymic epithelial tumors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d257ff1a088e4e45b74cec7c263b58b2
work_keys_str_mv	AT chunhaiyu dualenergyctperfusionimagingfordifferentiatingwhosubtypesofthymicepithelialtumors AT tingli dualenergyctperfusionimagingfordifferentiatingwhosubtypesofthymicepithelialtumors AT ruipingzhang dualenergyctperfusionimagingfordifferentiatingwhosubtypesofthymicepithelialtumors AT xiaotangyang dualenergyctperfusionimagingfordifferentiatingwhosubtypesofthymicepithelialtumors AT zhaoyang dualenergyctperfusionimagingfordifferentiatingwhosubtypesofthymicepithelialtumors AT leixin dualenergyctperfusionimagingfordifferentiatingwhosubtypesofthymicepithelialtumors AT zhikaizhao dualenergyctperfusionimagingfordifferentiatingwhosubtypesofthymicepithelialtumors
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Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors

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