Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment

Background. In case of a corneal burn injury, cell transplantation into the damaged area must be performed within the first 12 hours, which makes it impossible to use autologous stem cells. One solution to this problem may be the use of peptides, derived from cultured stem cells in the treatment and...

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Autores principales:	A. V. Tereshchenko, I. G. Trifanenkova, A. M. Kodunov, A. A. Temnov, A. N. Sklifas
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	corneal thermal burn corneal neovascularization mesenchymal stem cells peptides experimental studies Science Q
Acceso en línea:	https://doaj.org/article/d259fb3c513c4ddaa3a37e3c3eb2885a
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spelling	oai:doaj.org-article:d259fb3c513c4ddaa3a37e3c3eb2885a2021-11-23T06:14:42ZEffect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment2541-94202587-959610.29413/ABS.2019-4.4.4https://doaj.org/article/d259fb3c513c4ddaa3a37e3c3eb2885a2019-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2118https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. In case of a corneal burn injury, cell transplantation into the damaged area must be performed within the first 12 hours, which makes it impossible to use autologous stem cells. One solution to this problem may be the use of peptides, derived from cultured stem cells in the treatment and prevention of complications in a burn eye disease. Aims: To study the dynamics of corneal tissue repair under the influence of a peptide solution on a corneal thermal burn model.Materials and methods. The study included 20 rabbits (20 eyes) of the gray Chinchilla breed weighing from 2.5 to 3.2 kg with a corneal thermal burn model. Depending on the method of treatment used, the animals were divided in two groups of 10 rabbits (10 eyes). In the experimental group, instillations of a peptide solution were used to treat corneal thermal burns; in the control treatment was carried out with a solution of moxifloxacin and gel “Solcoseryl”. On the 1st, 3rd, 7th, 14th, 30th days in each group, two animals were sacrificed to conduct a morphological study of the cornea. Results. In the experimental group, by the 30th day, according to a histological study, the inflammatory process was completed both on the surface and inside the cornea, with a tendency to restore its normal structure. In the control group of animals, significantly longer periods of corneal recovery and preservation of inflammation, despite the received therapy, were observed.Conclusions. The use of the peptide preparation is promising in the treatment of corneal thermal burn. Further research is needed in this area.A. V. TereshchenkoI. G. TrifanenkovaA. M. KodunovA. A. TemnovA. N. SklifasScientific Сentre for Family Health and Human Reproduction Problemsarticlecorneal thermal burncorneal neovascularizationmesenchymal stem cellspeptidesexperimental studiesScienceQRUActa Biomedica Scientifica, Vol 4, Iss 4, Pp 30-35 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	corneal thermal burn corneal neovascularization mesenchymal stem cells peptides experimental studies Science Q
spellingShingle	corneal thermal burn corneal neovascularization mesenchymal stem cells peptides experimental studies Science Q A. V. Tereshchenko I. G. Trifanenkova A. M. Kodunov A. A. Temnov A. N. Sklifas Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment
description	Background. In case of a corneal burn injury, cell transplantation into the damaged area must be performed within the first 12 hours, which makes it impossible to use autologous stem cells. One solution to this problem may be the use of peptides, derived from cultured stem cells in the treatment and prevention of complications in a burn eye disease. Aims: To study the dynamics of corneal tissue repair under the influence of a peptide solution on a corneal thermal burn model.Materials and methods. The study included 20 rabbits (20 eyes) of the gray Chinchilla breed weighing from 2.5 to 3.2 kg with a corneal thermal burn model. Depending on the method of treatment used, the animals were divided in two groups of 10 rabbits (10 eyes). In the experimental group, instillations of a peptide solution were used to treat corneal thermal burns; in the control treatment was carried out with a solution of moxifloxacin and gel “Solcoseryl”. On the 1st, 3rd, 7th, 14th, 30th days in each group, two animals were sacrificed to conduct a morphological study of the cornea. Results. In the experimental group, by the 30th day, according to a histological study, the inflammatory process was completed both on the surface and inside the cornea, with a tendency to restore its normal structure. In the control group of animals, significantly longer periods of corneal recovery and preservation of inflammation, despite the received therapy, were observed.Conclusions. The use of the peptide preparation is promising in the treatment of corneal thermal burn. Further research is needed in this area.
format	article
author	A. V. Tereshchenko I. G. Trifanenkova A. M. Kodunov A. A. Temnov A. N. Sklifas
author_facet	A. V. Tereshchenko I. G. Trifanenkova A. M. Kodunov A. A. Temnov A. N. Sklifas
author_sort	A. V. Tereshchenko
title	Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment
title_short	Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment
title_full	Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment
title_fullStr	Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment
title_full_unstemmed	Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment
title_sort	effect of ligand peptides on post-burn inflammation of damaged corneal tissue in experiment
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/d259fb3c513c4ddaa3a37e3c3eb2885a
work_keys_str_mv	AT avtereshchenko effectofligandpeptidesonpostburninflammationofdamagedcornealtissueinexperiment AT igtrifanenkova effectofligandpeptidesonpostburninflammationofdamagedcornealtissueinexperiment AT amkodunov effectofligandpeptidesonpostburninflammationofdamagedcornealtissueinexperiment AT aatemnov effectofligandpeptidesonpostburninflammationofdamagedcornealtissueinexperiment AT ansklifas effectofligandpeptidesonpostburninflammationofdamagedcornealtissueinexperiment
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Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment

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