Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Paula dos Passos Menezes,1 Luiza Abrahão Frank,2 Bruno dos Santos Lima,1 Yasmim Maria Barbosa Gomes de Carvalho,1 Mairim Russo Serafini,1 Lucindo José Quintans-Júnior,3 Adriana Raffin Pohlmann,4 Sílvia Stanisçuaski Guterres,2 Adriano Antunes de...

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Autores principales:	Menezes PP, Frank LA, Lima BS, Carvalho YMBG, Serafini MR, Quintans-Júnior LJ, Pohlmann AR, Guterres SS, Araújo AAS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	lipid-core nanocapsules polymer hesperetin fabrics impregnation medical textiles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d25b1e05034d46f2b1c207cbd93add7b
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spelling	oai:doaj.org-article:d25b1e05034d46f2b1c207cbd93add7b2021-12-02T03:10:57ZHesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery1178-2013https://doaj.org/article/d25b1e05034d46f2b1c207cbd93add7b2017-03-01T00:00:00Zhttps://www.dovepress.com/hesperetin-loaded-lipid-core-nanocapsules-in-polyamide-a-new-textile-f-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Paula dos Passos Menezes,1 Luiza Abrahão Frank,2 Bruno dos Santos Lima,1 Yasmim Maria Barbosa Gomes de Carvalho,1 Mairim Russo Serafini,1 Lucindo José Quintans-Júnior,3 Adriana Raffin Pohlmann,4 Sílvia Stanisçuaski Guterres,2 Adriano Antunes de Souza Araújo1 1Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; 2College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; 3Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; 4Institute of Chemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil Abstract: Chronic venous insufficiency is characterized by chronic reflux disorder of blood from the peripheral to the central vein, with subsequent venous hypertension and resulting changes in the skin. Traditionally, nonsurgical treatments relied on the use of compression therapy, and more recently a variety of flavonoids have been shown to have positive effects. There have also been developments of more effective drug delivery systems using various textiles and nanotechnology to provide new therapeutic options. Our objective was to use nanotechnology to develop a new formulation containing hesperetin (Hst), a substance not previously used in the treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of venous diseases. We prepared the nanocapsules using the interfacial deposition of preformed polymer method with an Hst concentration of 0.5 mg/mL and then characterized the size and distribution of particles. To quantify the Hst in the samples, we developed an analytical method using high-performance liquid chromatography. Studies of encapsulation efficiency (98.81%±0.28%), microscopy, drug release (free-Hst: 104.96%±12.83%; lipid-core nanocapsule-Hst: 69.90%±1.33%), penetration/permeation, drug content (0.46±0.01 mg/mL) and the effect of washing the textile after drug impregnation were performed as part of the study. The results showed that nanoparticles of a suitable size and distribution with controlled release of the drug and penetration/permeation into the skin layers were achieved. Furthermore, it was established that polyamide was able to hold more of the drug, with a 2.54 times higher content than the cotton fiber; after one wash and after five washes, this relation was 2.80 times higher. In conclusion, this is a promising therapeutic alternative to be further studied in clinical trials. Keywords: lipid-core nanocapsules, polymer, hesperetin, fabrics, impregnation, medical textiles, polyamide, poly(ε-caprolactone)Menezes PPFrank LALima BSCarvalho YMBGSerafini MRQuintans-Júnior LJPohlmann ARGuterres SSAraújo AASDove Medical Pressarticlelipid-core nanocapsulespolymerhesperetinfabricsimpregnationmedical textilesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2069-2079 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid-core nanocapsules polymer hesperetin fabrics impregnation medical textiles Medicine (General) R5-920
spellingShingle	lipid-core nanocapsules polymer hesperetin fabrics impregnation medical textiles Medicine (General) R5-920 Menezes PP Frank LA Lima BS Carvalho YMBG Serafini MR Quintans-Júnior LJ Pohlmann AR Guterres SS Araújo AAS Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery
description	Paula dos Passos Menezes,1 Luiza Abrahão Frank,2 Bruno dos Santos Lima,1 Yasmim Maria Barbosa Gomes de Carvalho,1 Mairim Russo Serafini,1 Lucindo José Quintans-Júnior,3 Adriana Raffin Pohlmann,4 Sílvia Stanisçuaski Guterres,2 Adriano Antunes de Souza Araújo1 1Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; 2College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; 3Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; 4Institute of Chemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil Abstract: Chronic venous insufficiency is characterized by chronic reflux disorder of blood from the peripheral to the central vein, with subsequent venous hypertension and resulting changes in the skin. Traditionally, nonsurgical treatments relied on the use of compression therapy, and more recently a variety of flavonoids have been shown to have positive effects. There have also been developments of more effective drug delivery systems using various textiles and nanotechnology to provide new therapeutic options. Our objective was to use nanotechnology to develop a new formulation containing hesperetin (Hst), a substance not previously used in the treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of venous diseases. We prepared the nanocapsules using the interfacial deposition of preformed polymer method with an Hst concentration of 0.5 mg/mL and then characterized the size and distribution of particles. To quantify the Hst in the samples, we developed an analytical method using high-performance liquid chromatography. Studies of encapsulation efficiency (98.81%±0.28%), microscopy, drug release (free-Hst: 104.96%±12.83%; lipid-core nanocapsule-Hst: 69.90%±1.33%), penetration/permeation, drug content (0.46±0.01 mg/mL) and the effect of washing the textile after drug impregnation were performed as part of the study. The results showed that nanoparticles of a suitable size and distribution with controlled release of the drug and penetration/permeation into the skin layers were achieved. Furthermore, it was established that polyamide was able to hold more of the drug, with a 2.54 times higher content than the cotton fiber; after one wash and after five washes, this relation was 2.80 times higher. In conclusion, this is a promising therapeutic alternative to be further studied in clinical trials. Keywords: lipid-core nanocapsules, polymer, hesperetin, fabrics, impregnation, medical textiles, polyamide, poly(ε-caprolactone)
format	article
author	Menezes PP Frank LA Lima BS Carvalho YMBG Serafini MR Quintans-Júnior LJ Pohlmann AR Guterres SS Araújo AAS
author_facet	Menezes PP Frank LA Lima BS Carvalho YMBG Serafini MR Quintans-Júnior LJ Pohlmann AR Guterres SS Araújo AAS
author_sort	Menezes PP
title	Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery
title_short	Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery
title_full	Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery
title_fullStr	Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery
title_full_unstemmed	Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery
title_sort	hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d25b1e05034d46f2b1c207cbd93add7b
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Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

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