The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid
Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC and albumin concentrations, interpretation of KFLC in CSF may...
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SAGE Publishing
2021
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oai:doaj.org-article:d25c375bbaa347e4b1ca831f181a4fc62021-11-19T23:03:19ZThe Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid1179-573510.1177/11795735211042166https://doaj.org/article/d25c375bbaa347e4b1ca831f181a4fc62021-11-01T00:00:00Zhttps://doi.org/10.1177/11795735211042166https://doaj.org/toc/1179-5735Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC and albumin concentrations, interpretation of KFLC in CSF may be influenced by these parameters. Methods In this two-center study, the influence of renal function (according to the CKD-EPI creatinine equation) on KFLC and albumin concentrations was investigated in patients with “physiological” (n = 139), “non-inflammatory” (n = 146), and “inflammatory” (n = 172) CSF profiles in respect to the KFLC index and the evaluation in quotient diagrams in reference to the hyperbolic reference range (KFLC IF). Results All sample groups displayed declining KFLC indices and KFLC IF values with decreasing renal function ( P -values between <.0001 and .0209). In “inflammatory” CSF profile samples, 15% of the patients presented a KFLC index <5.9 while 10% showed an intrathecal KFLC fraction below Q Kappa (lim), suggesting possible false negative KFLC results. Conclusions The influence of renal function should be considered while interpreting KFLC results in patients with neuroinflammatory diseases. The interpretation of KFLC in quotient diagrams is less susceptible to renal function impairment than the KFLC index and should be preferentially used.Franz F KonenPhilipp SchwenkenbecherUlrich WursterKonstantin F JendretzkyNora MöhnStefan GingeleKurt-Wolfram SühsMalte J HannichMatthias GrotheTorsten WitteMartin StangelMarie SüßeThomas SkripuletzSAGE PublishingarticleNeurology. Diseases of the nervous systemRC346-429ENJournal of Central Nervous System Disease, Vol 13 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Neurology. Diseases of the nervous system RC346-429 |
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Neurology. Diseases of the nervous system RC346-429 Franz F Konen Philipp Schwenkenbecher Ulrich Wurster Konstantin F Jendretzky Nora Möhn Stefan Gingele Kurt-Wolfram Sühs Malte J Hannich Matthias Grothe Torsten Witte Martin Stangel Marie Süße Thomas Skripuletz The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid |
| description |
Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC and albumin concentrations, interpretation of KFLC in CSF may be influenced by these parameters. Methods In this two-center study, the influence of renal function (according to the CKD-EPI creatinine equation) on KFLC and albumin concentrations was investigated in patients with “physiological” (n = 139), “non-inflammatory” (n = 146), and “inflammatory” (n = 172) CSF profiles in respect to the KFLC index and the evaluation in quotient diagrams in reference to the hyperbolic reference range (KFLC IF). Results All sample groups displayed declining KFLC indices and KFLC IF values with decreasing renal function ( P -values between <.0001 and .0209). In “inflammatory” CSF profile samples, 15% of the patients presented a KFLC index <5.9 while 10% showed an intrathecal KFLC fraction below Q Kappa (lim), suggesting possible false negative KFLC results. Conclusions The influence of renal function should be considered while interpreting KFLC results in patients with neuroinflammatory diseases. The interpretation of KFLC in quotient diagrams is less susceptible to renal function impairment than the KFLC index and should be preferentially used. |
| format |
article |
| author |
Franz F Konen Philipp Schwenkenbecher Ulrich Wurster Konstantin F Jendretzky Nora Möhn Stefan Gingele Kurt-Wolfram Sühs Malte J Hannich Matthias Grothe Torsten Witte Martin Stangel Marie Süße Thomas Skripuletz |
| author_facet |
Franz F Konen Philipp Schwenkenbecher Ulrich Wurster Konstantin F Jendretzky Nora Möhn Stefan Gingele Kurt-Wolfram Sühs Malte J Hannich Matthias Grothe Torsten Witte Martin Stangel Marie Süße Thomas Skripuletz |
| author_sort |
Franz F Konen |
| title |
The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid |
| title_short |
The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid |
| title_full |
The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid |
| title_fullStr |
The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid |
| title_full_unstemmed |
The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid |
| title_sort |
influence of renal function impairment on kappa free light chains in cerebrospinal fluid |
| publisher |
SAGE Publishing |
| publishDate |
2021 |
| url |
https://doaj.org/article/d25c375bbaa347e4b1ca831f181a4fc6 |
| work_keys_str_mv |
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