Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese

Genetic risk loci for tuberculosis (TB) have so far been identified in African and Russian populations. Here, the authors perform a three-stage GWAS for TB in Han Chinese populations and find two risk loci near ESRRB and TGM6 and further demonstrate that tgm6 protects mice from Mtb infection.

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Autores principales:	Ruijuan Zheng, Zhiqiang Li, Fusheng He, Haipeng Liu, Jianhua Chen, Jiayu Chen, Xuefeng Xie, Juan Zhou, Hao Chen, Xiangyang Wu, Juehui Wu, Boyu Chen, Yahui Liu, Haiyan Cui, Lin Fan, Wei Sha, Yin Liu, Jiqiang Wang, Xiaochen Huang, Linfeng Zhang, Feifan Xu, Jie Wang, Yonghong Feng, Lianhua Qin, Hua Yang, Zhonghua Liu, Zhenglin Cui, Feng Liu, Xinchun Chen, Shaorong Gao, Silong Sun, Yongyong Shi, Baoxue Ge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d25f58a54d96443bbd352c706c5d3f44
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d25f58a54d96443bbd352c706c5d3f442021-12-02T14:39:46ZGenome-wide association study identifies two risk loci for tuberculosis in Han Chinese10.1038/s41467-018-06539-w2041-1723https://doaj.org/article/d25f58a54d96443bbd352c706c5d3f442018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06539-whttps://doaj.org/toc/2041-1723Genetic risk loci for tuberculosis (TB) have so far been identified in African and Russian populations. Here, the authors perform a three-stage GWAS for TB in Han Chinese populations and find two risk loci near ESRRB and TGM6 and further demonstrate that tgm6 protects mice from Mtb infection.Ruijuan ZhengZhiqiang LiFusheng HeHaipeng LiuJianhua ChenJiayu ChenXuefeng XieJuan ZhouHao ChenXiangyang WuJuehui WuBoyu ChenYahui LiuHaiyan CuiLin FanWei ShaYin LiuJiqiang WangXiaochen HuangLinfeng ZhangFeifan XuJie WangYonghong FengLianhua QinHua YangZhonghua LiuZhenglin CuiFeng LiuXinchun ChenShaorong GaoSilong SunYongyong ShiBaoxue GeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruijuan Zheng Zhiqiang Li Fusheng He Haipeng Liu Jianhua Chen Jiayu Chen Xuefeng Xie Juan Zhou Hao Chen Xiangyang Wu Juehui Wu Boyu Chen Yahui Liu Haiyan Cui Lin Fan Wei Sha Yin Liu Jiqiang Wang Xiaochen Huang Linfeng Zhang Feifan Xu Jie Wang Yonghong Feng Lianhua Qin Hua Yang Zhonghua Liu Zhenglin Cui Feng Liu Xinchun Chen Shaorong Gao Silong Sun Yongyong Shi Baoxue Ge Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
description	Genetic risk loci for tuberculosis (TB) have so far been identified in African and Russian populations. Here, the authors perform a three-stage GWAS for TB in Han Chinese populations and find two risk loci near ESRRB and TGM6 and further demonstrate that tgm6 protects mice from Mtb infection.
format	article
author	Ruijuan Zheng Zhiqiang Li Fusheng He Haipeng Liu Jianhua Chen Jiayu Chen Xuefeng Xie Juan Zhou Hao Chen Xiangyang Wu Juehui Wu Boyu Chen Yahui Liu Haiyan Cui Lin Fan Wei Sha Yin Liu Jiqiang Wang Xiaochen Huang Linfeng Zhang Feifan Xu Jie Wang Yonghong Feng Lianhua Qin Hua Yang Zhonghua Liu Zhenglin Cui Feng Liu Xinchun Chen Shaorong Gao Silong Sun Yongyong Shi Baoxue Ge
author_facet	Ruijuan Zheng Zhiqiang Li Fusheng He Haipeng Liu Jianhua Chen Jiayu Chen Xuefeng Xie Juan Zhou Hao Chen Xiangyang Wu Juehui Wu Boyu Chen Yahui Liu Haiyan Cui Lin Fan Wei Sha Yin Liu Jiqiang Wang Xiaochen Huang Linfeng Zhang Feifan Xu Jie Wang Yonghong Feng Lianhua Qin Hua Yang Zhonghua Liu Zhenglin Cui Feng Liu Xinchun Chen Shaorong Gao Silong Sun Yongyong Shi Baoxue Ge
author_sort	Ruijuan Zheng
title	Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
title_short	Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
title_full	Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
title_fullStr	Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
title_full_unstemmed	Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
title_sort	genome-wide association study identifies two risk loci for tuberculosis in han chinese
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d25f58a54d96443bbd352c706c5d3f44
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Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese

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