B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
The enzyme ACE2 is involved in cardiac pathology and can counteract heart failure and other cardio-pulmonary diseases. Here the authors show that bacteria produce an ACE2-like enzyme that is effective in suppressing cardiac hypertrophy and fibrosis in mice.
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Nature Portfolio
2020
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oai:doaj.org-article:d26136e7b956463b9d355114f88c8f402021-12-02T15:39:20ZB38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction10.1038/s41467-020-14867-z2041-1723https://doaj.org/article/d26136e7b956463b9d355114f88c8f402020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14867-zhttps://doaj.org/toc/2041-1723The enzyme ACE2 is involved in cardiac pathology and can counteract heart failure and other cardio-pulmonary diseases. Here the authors show that bacteria produce an ACE2-like enzyme that is effective in suppressing cardiac hypertrophy and fibrosis in mice.Takafumi MinatoSatoru NirasawaTeruki SatoTomokazu YamaguchiMidori HoshizakiTadakatsu InagakiKazuhiko NakaharaTadashi YoshihashiRyo OzawaSaki YokotaMiyuki NatsuiSouichi KoyotaTaku YoshiyaKumiko Yoshizawa-KumagayeSatoru MotoyamaTakeshi GotohYoshikazu NakaokaJosef M. PenningerHiroyuki WatanabeYumiko ImaiSaori TakahashiKeiji KubaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Takafumi Minato Satoru Nirasawa Teruki Sato Tomokazu Yamaguchi Midori Hoshizaki Tadakatsu Inagaki Kazuhiko Nakahara Tadashi Yoshihashi Ryo Ozawa Saki Yokota Miyuki Natsui Souichi Koyota Taku Yoshiya Kumiko Yoshizawa-Kumagaye Satoru Motoyama Takeshi Gotoh Yoshikazu Nakaoka Josef M. Penninger Hiroyuki Watanabe Yumiko Imai Saori Takahashi Keiji Kuba B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction |
| description |
The enzyme ACE2 is involved in cardiac pathology and can counteract heart failure and other cardio-pulmonary diseases. Here the authors show that bacteria produce an ACE2-like enzyme that is effective in suppressing cardiac hypertrophy and fibrosis in mice. |
| format |
article |
| author |
Takafumi Minato Satoru Nirasawa Teruki Sato Tomokazu Yamaguchi Midori Hoshizaki Tadakatsu Inagaki Kazuhiko Nakahara Tadashi Yoshihashi Ryo Ozawa Saki Yokota Miyuki Natsui Souichi Koyota Taku Yoshiya Kumiko Yoshizawa-Kumagaye Satoru Motoyama Takeshi Gotoh Yoshikazu Nakaoka Josef M. Penninger Hiroyuki Watanabe Yumiko Imai Saori Takahashi Keiji Kuba |
| author_facet |
Takafumi Minato Satoru Nirasawa Teruki Sato Tomokazu Yamaguchi Midori Hoshizaki Tadakatsu Inagaki Kazuhiko Nakahara Tadashi Yoshihashi Ryo Ozawa Saki Yokota Miyuki Natsui Souichi Koyota Taku Yoshiya Kumiko Yoshizawa-Kumagaye Satoru Motoyama Takeshi Gotoh Yoshikazu Nakaoka Josef M. Penninger Hiroyuki Watanabe Yumiko Imai Saori Takahashi Keiji Kuba |
| author_sort |
Takafumi Minato |
| title |
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction |
| title_short |
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction |
| title_full |
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction |
| title_fullStr |
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction |
| title_full_unstemmed |
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction |
| title_sort |
b38-cap is a bacteria-derived ace2-like enzyme that suppresses hypertension and cardiac dysfunction |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/d26136e7b956463b9d355114f88c8f40 |
| work_keys_str_mv |
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