The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis
TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAs
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Nature Portfolio
2021
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oai:doaj.org-article:d26320e63277491b9c09179e1c48bfd52021-12-02T15:52:56ZThe TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis10.1038/s41467-021-21382-22041-1723https://doaj.org/article/d26320e63277491b9c09179e1c48bfd52021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21382-2https://doaj.org/toc/2041-1723TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAsHélène ScheerCaroline de AlmeidaEmilie FerrierQuentin SimonnotLaure PoirierDavid PfliegerFrançois M. SementSandrine KoechlerChristina PiermariaPaweł KrawczykSeweryn MroczekJohana ChicherLauriane KuhnAndrzej DziembowskiPhilippe HammannHélène ZuberDominique GagliardiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hélène Scheer Caroline de Almeida Emilie Ferrier Quentin Simonnot Laure Poirier David Pflieger François M. Sement Sandrine Koechler Christina Piermaria Paweł Krawczyk Seweryn Mroczek Johana Chicher Lauriane Kuhn Andrzej Dziembowski Philippe Hammann Hélène Zuber Dominique Gagliardi The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis |
| description |
TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAs |
| format |
article |
| author |
Hélène Scheer Caroline de Almeida Emilie Ferrier Quentin Simonnot Laure Poirier David Pflieger François M. Sement Sandrine Koechler Christina Piermaria Paweł Krawczyk Seweryn Mroczek Johana Chicher Lauriane Kuhn Andrzej Dziembowski Philippe Hammann Hélène Zuber Dominique Gagliardi |
| author_facet |
Hélène Scheer Caroline de Almeida Emilie Ferrier Quentin Simonnot Laure Poirier David Pflieger François M. Sement Sandrine Koechler Christina Piermaria Paweł Krawczyk Seweryn Mroczek Johana Chicher Lauriane Kuhn Andrzej Dziembowski Philippe Hammann Hélène Zuber Dominique Gagliardi |
| author_sort |
Hélène Scheer |
| title |
The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis |
| title_short |
The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis |
| title_full |
The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis |
| title_fullStr |
The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis |
| title_full_unstemmed |
The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis |
| title_sort |
tutase urt1 connects decapping activators and prevents the accumulation of excessively deadenylated mrnas to avoid sirna biogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d26320e63277491b9c09179e1c48bfd5 |
| work_keys_str_mv |
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