Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of synaptic inhibition along the CA1 dendritic tree.

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Autores principales:	Sergio Valbuena, Álvaro García, Wilfrid Mazier, Ana V. Paternain, Juan Lerma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d263a07d71f248b588f195680de08d05
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spelling	oai:doaj.org-article:d263a07d71f248b588f195680de08d052021-12-02T16:58:17ZUnbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model10.1038/s41467-019-13004-92041-1723https://doaj.org/article/d263a07d71f248b588f195680de08d052019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13004-9https://doaj.org/toc/2041-1723Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of synaptic inhibition along the CA1 dendritic tree.Sergio ValbuenaÁlvaro GarcíaWilfrid MazierAna V. PaternainJuan LermaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sergio Valbuena Álvaro García Wilfrid Mazier Ana V. Paternain Juan Lerma Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
description	Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of synaptic inhibition along the CA1 dendritic tree.
format	article
author	Sergio Valbuena Álvaro García Wilfrid Mazier Ana V. Paternain Juan Lerma
author_facet	Sergio Valbuena Álvaro García Wilfrid Mazier Ana V. Paternain Juan Lerma
author_sort	Sergio Valbuena
title	Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_short	Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_full	Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_fullStr	Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_full_unstemmed	Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_sort	unbalanced dendritic inhibition of ca1 neurons drives spatial-memory deficits in the ts2cje down syndrome model
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d263a07d71f248b588f195680de08d05
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Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

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