Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity

Kamyar Shameli1, Mansor Bin Ahmad1, Wan Md Zin Wan Yunus1, Nor Azowa Ibrahim1, Russly Abdul Rahman2, Maryam Jokar2,3, Majid Darroudi41Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of Food Technology, Faculty of Food Science and Technology, Un...

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Autores principales:	Kamyar Shameli, Mansor Bin Ahmad, Wan Md Zin Wan Yunus, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d26637ef4e7042e98f7fc185e6b4ae4a
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spelling	oai:doaj.org-article:d26637ef4e7042e98f7fc185e6b4ae4a2021-12-02T06:25:32ZSilver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity1176-91141178-2013https://doaj.org/article/d26637ef4e7042e98f7fc185e6b4ae4a2010-08-01T00:00:00Zhttp://www.dovepress.com/silverpoly-lactic-acid-nanocomposites-preparation-characterization-and-a4993https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Kamyar Shameli1, Mansor Bin Ahmad1, Wan Md Zin Wan Yunus1, Nor Azowa Ibrahim1, Russly Abdul Rahman2, Maryam Jokar2,3, Majid Darroudi41Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia; 3Department of Food Technology, Islamic Azad University, Damghan Branch, Damghan, Iran; 4Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Selangor, MalaysiaAbstract: In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller&ndash;Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.Keywords: antibacterial activity, silver nanoparticles, biodegradable, poly (lactic acid), Muller&ndash;Hinton agar. Kamyar ShameliMansor Bin AhmadWan Md Zin Wan Yunuset alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 573-579 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kamyar Shameli Mansor Bin Ahmad Wan Md Zin Wan Yunus et al Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
description	Kamyar Shameli1, Mansor Bin Ahmad1, Wan Md Zin Wan Yunus1, Nor Azowa Ibrahim1, Russly Abdul Rahman2, Maryam Jokar2,3, Majid Darroudi41Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia; 3Department of Food Technology, Islamic Azad University, Damghan Branch, Damghan, Iran; 4Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Selangor, MalaysiaAbstract: In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller&ndash;Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.Keywords: antibacterial activity, silver nanoparticles, biodegradable, poly (lactic acid), Muller&ndash;Hinton agar.
format	article
author	Kamyar Shameli Mansor Bin Ahmad Wan Md Zin Wan Yunus et al
author_facet	Kamyar Shameli Mansor Bin Ahmad Wan Md Zin Wan Yunus et al
author_sort	Kamyar Shameli
title	Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
title_short	Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
title_full	Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
title_fullStr	Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
title_full_unstemmed	Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
title_sort	silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/d26637ef4e7042e98f7fc185e6b4ae4a
work_keys_str_mv	AT kamyarshameli silverpolylacticacidnanocompositespreparationcharacterizationandantibacterialactivity AT mansorbinahmad silverpolylacticacidnanocompositespreparationcharacterizationandantibacterialactivity AT wanmdzinwanyunus silverpolylacticacidnanocompositespreparationcharacterizationandantibacterialactivity AT etal silverpolylacticacidnanocompositespreparationcharacterizationandantibacterialactivity
_version_	1718399963291975680

Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity

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