8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription.

8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription.

The occurrence of resistant viruses to any of the anti-HIV-1 compounds used in the current therapies against AIDS underlies the urge for the development of new drug targets and/or new drugs acting through novel mechanisms. While all anti-HIV-1 nucleoside analogues in clinical use and in clinical tri...

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Autores principales: Valérie Vivet-Boudou, Catherine Isel, Marwan Sleiman, Redmond Smyth, Nouha Ben Gaied, Patrick Barhoum, Géraldine Laumond, Guillaume Bec, Matthias Götte, Johnson Mak, Anne-Marie Aubertin, Alain Burger, Roland Marquet
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d26822192f44480dba292f5d7d2298a6
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