SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown

Abstract The Coronavirus Disease of 2019 (COVID-19) pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection. Mobility restrictions and the requirement of a medical prescription for serological testing for COVID-19 we...

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Autores principales:	Patricia Torres Martínez, Paula Diaque García, María Rubio Salas, Raquel Rodríguez Sánchez, José Avendaño-Ortíz, Sandra Guerrero-Monjo, Felipe García, Miguel Ángel Llamas, Eduardo López-Collazo, Paula Saz-Leal, Carlos del Fresno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d269ec257e01400eb3c822fd08728dd1
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spelling	oai:doaj.org-article:d269ec257e01400eb3c822fd08728dd12021-11-08T10:48:45ZSARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown10.1038/s41598-021-00990-42045-2322https://doaj.org/article/d269ec257e01400eb3c822fd08728dd12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00990-4https://doaj.org/toc/2045-2322Abstract The Coronavirus Disease of 2019 (COVID-19) pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection. Mobility restrictions and the requirement of a medical prescription for serological testing for COVID-19 were included among the control measures. Under this scenario, between April 15th and June 15th, 2020, we performed an observational study including 449 individuals allowed to be tested according to the governmental restrictions, i.e. fulfilling the following prescription requirements: manifestation of COVID-19-compatible symptoms, contact with a confirmed COVID-19 patient, or employment as an essential worker, including health care workers, firefighters and public safety personnel such as police. Importantly, a relevant feature of the studied cohort was that none of the participants had been hospitalized. We analyzed SARS-CoV-2 IgG seropositivity in this specific cohort, uncovering intrinsic features of great demographic interest. The overall rate of IgG seropositivity was 33.69% (95% CI: 29.27–38.21). This frequency was comparable among the different participant occupations. A RT-PCR positive test, contact with a household member previously tested positive and the presence of COVID-19-compatible symptoms were positively associated with IgG + results. Among these symptoms, ageusia/anosmia was positively and independently associated with SARS-CoV-2 IgG seropositivity, while odynophagia was inversely associated. However, fever, ageusia/anosmia and asthenia were the most frequent symptoms described by IgG + subjects. Therefore, our data illustrate how specific cohorts display particular characteristics that should be taken into account when studying population-wide SARS-CoV-2 seroprevalence and key defining symptoms of COVID-19.Patricia Torres MartínezPaula Diaque GarcíaMaría Rubio SalasRaquel Rodríguez SánchezJosé Avendaño-OrtízSandra Guerrero-MonjoFelipe GarcíaMiguel Ángel LlamasEduardo López-CollazoPaula Saz-LealCarlos del FresnoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patricia Torres Martínez Paula Diaque García María Rubio Salas Raquel Rodríguez Sánchez José Avendaño-Ortíz Sandra Guerrero-Monjo Felipe García Miguel Ángel Llamas Eduardo López-Collazo Paula Saz-Leal Carlos del Fresno SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown
description	Abstract The Coronavirus Disease of 2019 (COVID-19) pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection. Mobility restrictions and the requirement of a medical prescription for serological testing for COVID-19 were included among the control measures. Under this scenario, between April 15th and June 15th, 2020, we performed an observational study including 449 individuals allowed to be tested according to the governmental restrictions, i.e. fulfilling the following prescription requirements: manifestation of COVID-19-compatible symptoms, contact with a confirmed COVID-19 patient, or employment as an essential worker, including health care workers, firefighters and public safety personnel such as police. Importantly, a relevant feature of the studied cohort was that none of the participants had been hospitalized. We analyzed SARS-CoV-2 IgG seropositivity in this specific cohort, uncovering intrinsic features of great demographic interest. The overall rate of IgG seropositivity was 33.69% (95% CI: 29.27–38.21). This frequency was comparable among the different participant occupations. A RT-PCR positive test, contact with a household member previously tested positive and the presence of COVID-19-compatible symptoms were positively associated with IgG + results. Among these symptoms, ageusia/anosmia was positively and independently associated with SARS-CoV-2 IgG seropositivity, while odynophagia was inversely associated. However, fever, ageusia/anosmia and asthenia were the most frequent symptoms described by IgG + subjects. Therefore, our data illustrate how specific cohorts display particular characteristics that should be taken into account when studying population-wide SARS-CoV-2 seroprevalence and key defining symptoms of COVID-19.
format	article
author	Patricia Torres Martínez Paula Diaque García María Rubio Salas Raquel Rodríguez Sánchez José Avendaño-Ortíz Sandra Guerrero-Monjo Felipe García Miguel Ángel Llamas Eduardo López-Collazo Paula Saz-Leal Carlos del Fresno
author_facet	Patricia Torres Martínez Paula Diaque García María Rubio Salas Raquel Rodríguez Sánchez José Avendaño-Ortíz Sandra Guerrero-Monjo Felipe García Miguel Ángel Llamas Eduardo López-Collazo Paula Saz-Leal Carlos del Fresno
author_sort	Patricia Torres Martínez
title	SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown
title_short	SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown
title_full	SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown
title_fullStr	SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown
title_full_unstemmed	SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown
title_sort	sars-cov-2 igg seropositivity in a cohort of 449 non-hospitalized individuals during spanish covid-19 lockdown
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d269ec257e01400eb3c822fd08728dd1
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SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown

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