Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression

Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cells it acts to prevent spurious Xist expression thr...

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Autores principales:	Andrea Cerase, Alexander N. Young, Nerea Blanes Ruiz, Andreas Buness, Gabrielle M. Sant, Mirjam Arnold, Monica Di Giacomo, Michela Ascolani, Manish Kumar, Andreas Hierholzer, Giuseppe Trigiante, Sarah J. Marzi, Philip Avner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d26e720a693341bcb6cd62cfbe1b421b
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spelling	oai:doaj.org-article:d26e720a693341bcb6cd62cfbe1b421b2021-12-02T15:51:05ZChd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression10.1038/s42003-021-01945-12399-3642https://doaj.org/article/d26e720a693341bcb6cd62cfbe1b421b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01945-1https://doaj.org/toc/2399-3642Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cells it acts to prevent spurious Xist expression through blocking transcription factor binding to the Xist promoter.Andrea CeraseAlexander N. YoungNerea Blanes RuizAndreas BunessGabrielle M. SantMirjam ArnoldMonica Di GiacomoMichela AscolaniManish KumarAndreas HierholzerGiuseppe TrigianteSarah J. MarziPhilip AvnerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andrea Cerase Alexander N. Young Nerea Blanes Ruiz Andreas Buness Gabrielle M. Sant Mirjam Arnold Monica Di Giacomo Michela Ascolani Manish Kumar Andreas Hierholzer Giuseppe Trigiante Sarah J. Marzi Philip Avner Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
description	Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cells it acts to prevent spurious Xist expression through blocking transcription factor binding to the Xist promoter.
format	article
author	Andrea Cerase Alexander N. Young Nerea Blanes Ruiz Andreas Buness Gabrielle M. Sant Mirjam Arnold Monica Di Giacomo Michela Ascolani Manish Kumar Andreas Hierholzer Giuseppe Trigiante Sarah J. Marzi Philip Avner
author_facet	Andrea Cerase Alexander N. Young Nerea Blanes Ruiz Andreas Buness Gabrielle M. Sant Mirjam Arnold Monica Di Giacomo Michela Ascolani Manish Kumar Andreas Hierholzer Giuseppe Trigiante Sarah J. Marzi Philip Avner
author_sort	Andrea Cerase
title	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_short	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_full	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_fullStr	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_full_unstemmed	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_sort	chd8 regulates x chromosome inactivation in mouse through fine-tuning control of xist expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d26e720a693341bcb6cd62cfbe1b421b
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Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression

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