Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation

Abstract Pre‐clinical haematopoietic cell transplantation (HCT) studies in canines have proven to be invaluable for establishing HCT as a highly successful clinical option for the treatment of malignant and non‐malignant haematological diseases in humans. Additionally, studies in canines have shown...

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Autores principales:	Scott S. Graves, Rainer Storb
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	canine kidney lymphoma stem cell transplantation Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/d270e6c7822e4b129576c86994021aca
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spelling	oai:doaj.org-article:d270e6c7822e4b129576c86994021aca2021-11-19T17:14:25ZEvolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation2053-109510.1002/vms3.601https://doaj.org/article/d270e6c7822e4b129576c86994021aca2021-11-01T00:00:00Zhttps://doi.org/10.1002/vms3.601https://doaj.org/toc/2053-1095Abstract Pre‐clinical haematopoietic cell transplantation (HCT) studies in canines have proven to be invaluable for establishing HCT as a highly successful clinical option for the treatment of malignant and non‐malignant haematological diseases in humans. Additionally, studies in canines have shown that immune tolerance, established following HCT, enabled transplantation of solid organs without the need of lifelong immunosuppression. This progress has been possible due to multiple biological similarities between dog and mankind. In this review, the hurdles that were overcome and the methods that were developed in the dog HCT model which made HCT clinically possible are examined. The results of these studies justify the question whether HCT can be used in the veterinary clinical practice for more wide‐spread successful treatment of canine haematologic and non‐haematologic disorders and whether it is prudent to do so.Scott S. GravesRainer StorbWileyarticlecaninekidneylymphomastem celltransplantationVeterinary medicineSF600-1100ENVeterinary Medicine and Science, Vol 7, Iss 6, Pp 2156-2171 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	canine kidney lymphoma stem cell transplantation Veterinary medicine SF600-1100
spellingShingle	canine kidney lymphoma stem cell transplantation Veterinary medicine SF600-1100 Scott S. Graves Rainer Storb Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
description	Abstract Pre‐clinical haematopoietic cell transplantation (HCT) studies in canines have proven to be invaluable for establishing HCT as a highly successful clinical option for the treatment of malignant and non‐malignant haematological diseases in humans. Additionally, studies in canines have shown that immune tolerance, established following HCT, enabled transplantation of solid organs without the need of lifelong immunosuppression. This progress has been possible due to multiple biological similarities between dog and mankind. In this review, the hurdles that were overcome and the methods that were developed in the dog HCT model which made HCT clinically possible are examined. The results of these studies justify the question whether HCT can be used in the veterinary clinical practice for more wide‐spread successful treatment of canine haematologic and non‐haematologic disorders and whether it is prudent to do so.
format	article
author	Scott S. Graves Rainer Storb
author_facet	Scott S. Graves Rainer Storb
author_sort	Scott S. Graves
title	Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
title_short	Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
title_full	Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
title_fullStr	Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
title_full_unstemmed	Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
title_sort	evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/d270e6c7822e4b129576c86994021aca
work_keys_str_mv	AT scottsgraves evolutionofhaematopoieticcelltransplantationforcanineblooddisordersandaplatformforsolidorgantransplantation AT rainerstorb evolutionofhaematopoieticcelltransplantationforcanineblooddisordersandaplatformforsolidorgantransplantation
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Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation

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