Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency

Eye lens cells are highly enriched in cholesterol that sustains lens transparency, and disruption of cholesterol biosynthesis leads to cataracts. The authors show that cholesterol biosynthesis regulated by Qki is essential for maintenance of membrane integrity of lens cells and proper protein foldin...

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Autores principales:	Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d277186ce32543ea986dbee11a0ed576
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spelling	oai:doaj.org-article:d277186ce32543ea986dbee11a0ed5762021-12-02T14:58:43ZQki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency10.1038/s41467-021-22782-02041-1723https://doaj.org/article/d277186ce32543ea986dbee11a0ed5762021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22782-0https://doaj.org/toc/2041-1723Eye lens cells are highly enriched in cholesterol that sustains lens transparency, and disruption of cholesterol biosynthesis leads to cataracts. The authors show that cholesterol biosynthesis regulated by Qki is essential for maintenance of membrane integrity of lens cells and proper protein folding.Seula ShinHao ZhouChenxi HeYanjun WeiYunfei WangTakashi ShinguAiliang ZengShaobo WangXin ZhouHongtao LiQiang ZhangQinling MoJiafu LongFei LanYiwen ChenJian HuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seula Shin Hao Zhou Chenxi He Yanjun Wei Yunfei Wang Takashi Shingu Ailiang Zeng Shaobo Wang Xin Zhou Hongtao Li Qiang Zhang Qinling Mo Jiafu Long Fei Lan Yiwen Chen Jian Hu Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
description	Eye lens cells are highly enriched in cholesterol that sustains lens transparency, and disruption of cholesterol biosynthesis leads to cataracts. The authors show that cholesterol biosynthesis regulated by Qki is essential for maintenance of membrane integrity of lens cells and proper protein folding.
format	article
author	Seula Shin Hao Zhou Chenxi He Yanjun Wei Yunfei Wang Takashi Shingu Ailiang Zeng Shaobo Wang Xin Zhou Hongtao Li Qiang Zhang Qinling Mo Jiafu Long Fei Lan Yiwen Chen Jian Hu
author_facet	Seula Shin Hao Zhou Chenxi He Yanjun Wei Yunfei Wang Takashi Shingu Ailiang Zeng Shaobo Wang Xin Zhou Hongtao Li Qiang Zhang Qinling Mo Jiafu Long Fei Lan Yiwen Chen Jian Hu
author_sort	Seula Shin
title	Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
title_short	Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
title_full	Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
title_fullStr	Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
title_full_unstemmed	Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
title_sort	qki activates srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d277186ce32543ea986dbee11a0ed576
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Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency

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