Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope

Abstract To propose a new test to evaluate the autonomic nervous system in patients with syncope: Multimodal Monitoring for Diagnosis of Dysautonomia (MMDD). We included 21 patients with syncope (16 female, 6 male, mean age 43.5 years) and 21 with no-syncope subjects (15 female, 7 male, mean age 45....

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Autores principales:	Juan Nader-Kawachi, Paulo C. Manrique-Mirón, Yaima C. Pino-Peña, María L. Andrade-Magdaleno, Jesús López-Estrada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2787d14cd4349b2b9b4c8e2eeec10da
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spelling	oai:doaj.org-article:d2787d14cd4349b2b9b4c8e2eeec10da2021-12-02T16:45:40ZFeasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope10.1038/s41598-020-70701-y2045-2322https://doaj.org/article/d2787d14cd4349b2b9b4c8e2eeec10da2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70701-yhttps://doaj.org/toc/2045-2322Abstract To propose a new test to evaluate the autonomic nervous system in patients with syncope: Multimodal Monitoring for Diagnosis of Dysautonomia (MMDD). We included 21 patients with syncope (16 female, 6 male, mean age 43.5 years) and 21 with no-syncope subjects (15 female, 7 male, mean age 45.1 years) to perform a test of nine 2-min stages: four while resting and four during active testing of autonomic response. Transcranial-Doppler, electrocardiogram, and photoplethysmography blood pressure pulse-to-pulse monitoring, allow registering six variables from the Middle Cerebral Artery and four from the Cardiovascular System. We analyze each variable's mean differences in each stage and its change when they pass from one stage to another with the T and Z tests. To understand the significance of the change, we use a logistic regression model for a certain subgroup of variables. Since we have a small dataset, we use the bootstrap technique to infer the general behavior that characterizes a syncope. Our data confirm differences between syncope and non-syncope patients during MMDD stress stages 2, 4, 6 and 8. Bootstrap and multivariate logistic regression allow us to identify which sets of variables in each of these stages of the MMDD are sufficiently sensitive to recognizing syncope. MMDD protocol can recognize a syncope patient with some confidence by detecting subtle changes in the autonomic nervous system. This protocol encourages us to continue to study the effectiveness of MMDD protocol allowing a new approach to future research.Juan Nader-KawachiPaulo C. Manrique-MirónYaima C. Pino-PeñaMaría L. Andrade-MagdalenoJesús López-EstradaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Nader-Kawachi Paulo C. Manrique-Mirón Yaima C. Pino-Peña María L. Andrade-Magdaleno Jesús López-Estrada Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope
description	Abstract To propose a new test to evaluate the autonomic nervous system in patients with syncope: Multimodal Monitoring for Diagnosis of Dysautonomia (MMDD). We included 21 patients with syncope (16 female, 6 male, mean age 43.5 years) and 21 with no-syncope subjects (15 female, 7 male, mean age 45.1 years) to perform a test of nine 2-min stages: four while resting and four during active testing of autonomic response. Transcranial-Doppler, electrocardiogram, and photoplethysmography blood pressure pulse-to-pulse monitoring, allow registering six variables from the Middle Cerebral Artery and four from the Cardiovascular System. We analyze each variable's mean differences in each stage and its change when they pass from one stage to another with the T and Z tests. To understand the significance of the change, we use a logistic regression model for a certain subgroup of variables. Since we have a small dataset, we use the bootstrap technique to infer the general behavior that characterizes a syncope. Our data confirm differences between syncope and non-syncope patients during MMDD stress stages 2, 4, 6 and 8. Bootstrap and multivariate logistic regression allow us to identify which sets of variables in each of these stages of the MMDD are sufficiently sensitive to recognizing syncope. MMDD protocol can recognize a syncope patient with some confidence by detecting subtle changes in the autonomic nervous system. This protocol encourages us to continue to study the effectiveness of MMDD protocol allowing a new approach to future research.
format	article
author	Juan Nader-Kawachi Paulo C. Manrique-Mirón Yaima C. Pino-Peña María L. Andrade-Magdaleno Jesús López-Estrada
author_facet	Juan Nader-Kawachi Paulo C. Manrique-Mirón Yaima C. Pino-Peña María L. Andrade-Magdaleno Jesús López-Estrada
author_sort	Juan Nader-Kawachi
title	Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope
title_short	Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope
title_full	Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope
title_fullStr	Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope
title_full_unstemmed	Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope
title_sort	feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d2787d14cd4349b2b9b4c8e2eeec10da
work_keys_str_mv	AT juannaderkawachi feasibilityofanewfreemobilityproceduretoevaluatethefunctionoftheautonomicnervoussysteminpatientswithsyncope AT paulocmanriquemiron feasibilityofanewfreemobilityproceduretoevaluatethefunctionoftheautonomicnervoussysteminpatientswithsyncope AT yaimacpinopena feasibilityofanewfreemobilityproceduretoevaluatethefunctionoftheautonomicnervoussysteminpatientswithsyncope AT marialandrademagdaleno feasibilityofanewfreemobilityproceduretoevaluatethefunctionoftheautonomicnervoussysteminpatientswithsyncope AT jesuslopezestrada feasibilityofanewfreemobilityproceduretoevaluatethefunctionoftheautonomicnervoussysteminpatientswithsyncope
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Feasibility of a new free mobility procedure to evaluate the function of the autonomic nervous system in patients with syncope

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