Skin models for the testing of transdermal drugs

Eman Abd,1 Shereen A Yousef,1 Michael N Pastore,2 Krishna Telaprolu,1 Yousuf H Mohammed,1 Sarika Namjoshi,1 Jeffrey E Grice,1 Michael S Roberts1,2 1Translational Research Institute, School of Medicine, University of Queensland, Brisbane, 2School of Pharmacy and Medical Sciences, University of South...

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Autores principales:	Abd E, Yousuf SA, Pastore MN, Telaprolu K, Mohammed YH, Namjoshi S, Grice JE, Roberts MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	skin absorption ex vivo in vitro excised skin reconstructed skin bioequivalence IVPT Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d27df308f517406bbda52835292f9c2a
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spelling	oai:doaj.org-article:d27df308f517406bbda52835292f9c2a2021-12-02T05:52:00ZSkin models for the testing of transdermal drugs1179-1438https://doaj.org/article/d27df308f517406bbda52835292f9c2a2016-10-01T00:00:00Zhttps://www.dovepress.com/skin-models-for-the-testing-of-transdermal-drugs-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Eman Abd,1 Shereen A Yousef,1 Michael N Pastore,2 Krishna Telaprolu,1 Yousuf H Mohammed,1 Sarika Namjoshi,1 Jeffrey E Grice,1 Michael S Roberts1,2 1Translational Research Institute, School of Medicine, University of Queensland, Brisbane, 2School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia Abstract: The assessment of percutaneous permeation of molecules is a key step in the evaluation of dermal or transdermal delivery systems. If the drugs are intended for delivery to humans, the most appropriate setting in which to do the assessment is the in vivo human. However, this may not be possible for ethical, practical, or economic reasons, particularly in the early phases of development. It is thus necessary to find alternative methods using accessible and reproducible surrogates for in vivo human skin. A range of models has been developed, including ex vivo human skin, usually obtained from cadavers or plastic surgery patients, ex vivo animal skin, and artificial or reconstructed skin models. Increasingly, largely driven by regulatory authorities and industry, there is a focus on developing standardized techniques and protocols. With this comes the need to demonstrate that the surrogate models produce results that correlate with those from in vivo human studies and that they can be used to show bioequivalence of different topical products. This review discusses the alternative skin models that have been developed as surrogates for normal and diseased skin and examines the concepts of using model systems for in vitro–in vivo correlation and the demonstration of bioequivalence. Keywords: percutaneous permeation, dermal delivery, transdermal, bioequivalence, ex vivo skin models, reconstructed skinAbd EYousuf SAPastore MNTelaprolu KMohammed YHNamjoshi SGrice JERoberts MSDove Medical Pressarticleskin absorptionex vivoin vitroexcised skinreconstructed skinbioequivalenceIVPTTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 8, Pp 163-176 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin absorption ex vivo in vitro excised skin reconstructed skin bioequivalence IVPT Therapeutics. Pharmacology RM1-950
spellingShingle	skin absorption ex vivo in vitro excised skin reconstructed skin bioequivalence IVPT Therapeutics. Pharmacology RM1-950 Abd E Yousuf SA Pastore MN Telaprolu K Mohammed YH Namjoshi S Grice JE Roberts MS Skin models for the testing of transdermal drugs
description	Eman Abd,1 Shereen A Yousef,1 Michael N Pastore,2 Krishna Telaprolu,1 Yousuf H Mohammed,1 Sarika Namjoshi,1 Jeffrey E Grice,1 Michael S Roberts1,2 1Translational Research Institute, School of Medicine, University of Queensland, Brisbane, 2School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia Abstract: The assessment of percutaneous permeation of molecules is a key step in the evaluation of dermal or transdermal delivery systems. If the drugs are intended for delivery to humans, the most appropriate setting in which to do the assessment is the in vivo human. However, this may not be possible for ethical, practical, or economic reasons, particularly in the early phases of development. It is thus necessary to find alternative methods using accessible and reproducible surrogates for in vivo human skin. A range of models has been developed, including ex vivo human skin, usually obtained from cadavers or plastic surgery patients, ex vivo animal skin, and artificial or reconstructed skin models. Increasingly, largely driven by regulatory authorities and industry, there is a focus on developing standardized techniques and protocols. With this comes the need to demonstrate that the surrogate models produce results that correlate with those from in vivo human studies and that they can be used to show bioequivalence of different topical products. This review discusses the alternative skin models that have been developed as surrogates for normal and diseased skin and examines the concepts of using model systems for in vitro–in vivo correlation and the demonstration of bioequivalence. Keywords: percutaneous permeation, dermal delivery, transdermal, bioequivalence, ex vivo skin models, reconstructed skin
format	article
author	Abd E Yousuf SA Pastore MN Telaprolu K Mohammed YH Namjoshi S Grice JE Roberts MS
author_facet	Abd E Yousuf SA Pastore MN Telaprolu K Mohammed YH Namjoshi S Grice JE Roberts MS
author_sort	Abd E
title	Skin models for the testing of transdermal drugs
title_short	Skin models for the testing of transdermal drugs
title_full	Skin models for the testing of transdermal drugs
title_fullStr	Skin models for the testing of transdermal drugs
title_full_unstemmed	Skin models for the testing of transdermal drugs
title_sort	skin models for the testing of transdermal drugs
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d27df308f517406bbda52835292f9c2a
work_keys_str_mv	AT abde skinmodelsforthetestingoftransdermaldrugs AT yousufsa skinmodelsforthetestingoftransdermaldrugs AT pastoremn skinmodelsforthetestingoftransdermaldrugs AT telaproluk skinmodelsforthetestingoftransdermaldrugs AT mohammedyh skinmodelsforthetestingoftransdermaldrugs AT namjoshis skinmodelsforthetestingoftransdermaldrugs AT griceje skinmodelsforthetestingoftransdermaldrugs AT robertsms skinmodelsforthetestingoftransdermaldrugs
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Skin models for the testing of transdermal drugs

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