FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population
Kun Lin,1,2,* Linyuan Zhang,1,2,* Yishuai Wang,1– 3,* Jinqing Li,1 Yufen Xu,1 Di Che,1 Hanran Mai,4 Hongyan Yu,1 Lanyan Fu,1 Bing Wei,2 Zhiyong Jiang,2 Lei Pi,1 Xiaoqiong Gu1,2 1Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d28746bb14644da8a44949bb66180a5b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d28746bb14644da8a44949bb66180a5b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d28746bb14644da8a44949bb66180a5b2021-12-02T17:44:39ZFNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population1178-7031https://doaj.org/article/d28746bb14644da8a44949bb66180a5b2021-06-01T00:00:00Zhttps://www.dovepress.com/fndc1-polymorphism-rs3003174-c--t-increased-the-incidence-of-coronary--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Kun Lin,1,2,* Linyuan Zhang,1,2,* Yishuai Wang,1– 3,* Jinqing Li,1 Yufen Xu,1 Di Che,1 Hanran Mai,4 Hongyan Yu,1 Lanyan Fu,1 Bing Wei,2 Zhiyong Jiang,2 Lei Pi,1 Xiaoqiong Gu1,2 1Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China; 2Department of Blood Transfusion and Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China; 3School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, People’s Republic of China; 4Department of Andrology, Guangzhou Women and Children’s Medical Center. Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoqiong Gu; Lei Pi Email guxiaoqiong@gwcmc.org; pilei@gwcmc.orgBackground: A large number of studies demonstrated that the key to the occurrence and development of Kawasaki disease (KD) is the over-activation of immune cells and the generation of various inflammatory factors, leading to the imbalance of the immune system. Recently, mutations in the FNDC1 gene have been shown to be associated with inflammatory responses. However, there have been no reports on the relationship between FNDC1 gene and KD so far.Methods: We enrolled 1611 controls and 1459 patients with KD, including 372 patients with coronary artery aneurysm (CAA) and 179 patients with coronary artery lesion (CAL). The relationship between FNDC1 rs3003174 polymorphism and KD with CAA or without CAA was investigated.Results: This study showed no evidence that the association between FNDC1 rs3003174 C>T polymorphism and KD susceptibility was statistically significant (CT versus CC: adjusted odds ratio (OR) =0.897, 95% confidence interval (CI) =0.769– 1.045, P=0.162; TT versus CC: adjusted OR=0.995, 95% CI=0.786– 1.260, P=0.968; dominant model: adjusted OR=0.916, 95% CI=0.792– 1.059, P=0.235; and recessive model: adjusted OR=1.055, 95% CI=0.845– 1.316, P=0.638). However, our further stratified analysis in the control and KD group bore out that the incidence of TT genotype of FNDC1 rs3003174 C > T polymorphism was higher than that of CC/CT genotype in KD patients stratified by CAA (adjusted OR=1.437, 95% CI=1.034– 1.996, P=0.031). Moreover, a stratified analysis of age and gender in KD patients indicated that the rs3003174 TT genotype increased the risk of CAA formation in aged ≦60 months (CC/CT vs TT: adjusted OR=1.580, 95% CI=1.106– 2.259, P=0.012) and male (CC/CT vs TT: adjusted OR=1.653, 95% CI=1.101– 2.481, P=0.015) KD patients.Conclusion: The results of this study demonstrated that the FNDC1 rs3003174 C>T polymorphism may be a hazard factor in the formation of CAA in KD patients that was not disclosed before.Keywords: coronary artery aneurysm, Kawasaki disease, fibronectin type III domain containing 1, polymorphismsLin KZhang LWang YLi JXu YChe DMai HYu HFu LWei BJiang ZPi LGu XDove Medical Pressarticlecoronary artery aneurysmkawasaki diseasefibronectin type iii domain containing 1polymorphismsPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2633-2640 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
coronary artery aneurysm kawasaki disease fibronectin type iii domain containing 1 polymorphisms Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
coronary artery aneurysm kawasaki disease fibronectin type iii domain containing 1 polymorphisms Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Lin K Zhang L Wang Y Li J Xu Y Che D Mai H Yu H Fu L Wei B Jiang Z Pi L Gu X FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population |
| description |
Kun Lin,1,2,* Linyuan Zhang,1,2,* Yishuai Wang,1– 3,* Jinqing Li,1 Yufen Xu,1 Di Che,1 Hanran Mai,4 Hongyan Yu,1 Lanyan Fu,1 Bing Wei,2 Zhiyong Jiang,2 Lei Pi,1 Xiaoqiong Gu1,2 1Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China; 2Department of Blood Transfusion and Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China; 3School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, People’s Republic of China; 4Department of Andrology, Guangzhou Women and Children’s Medical Center. Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoqiong Gu; Lei Pi Email guxiaoqiong@gwcmc.org; pilei@gwcmc.orgBackground: A large number of studies demonstrated that the key to the occurrence and development of Kawasaki disease (KD) is the over-activation of immune cells and the generation of various inflammatory factors, leading to the imbalance of the immune system. Recently, mutations in the FNDC1 gene have been shown to be associated with inflammatory responses. However, there have been no reports on the relationship between FNDC1 gene and KD so far.Methods: We enrolled 1611 controls and 1459 patients with KD, including 372 patients with coronary artery aneurysm (CAA) and 179 patients with coronary artery lesion (CAL). The relationship between FNDC1 rs3003174 polymorphism and KD with CAA or without CAA was investigated.Results: This study showed no evidence that the association between FNDC1 rs3003174 C>T polymorphism and KD susceptibility was statistically significant (CT versus CC: adjusted odds ratio (OR) =0.897, 95% confidence interval (CI) =0.769– 1.045, P=0.162; TT versus CC: adjusted OR=0.995, 95% CI=0.786– 1.260, P=0.968; dominant model: adjusted OR=0.916, 95% CI=0.792– 1.059, P=0.235; and recessive model: adjusted OR=1.055, 95% CI=0.845– 1.316, P=0.638). However, our further stratified analysis in the control and KD group bore out that the incidence of TT genotype of FNDC1 rs3003174 C > T polymorphism was higher than that of CC/CT genotype in KD patients stratified by CAA (adjusted OR=1.437, 95% CI=1.034– 1.996, P=0.031). Moreover, a stratified analysis of age and gender in KD patients indicated that the rs3003174 TT genotype increased the risk of CAA formation in aged ≦60 months (CC/CT vs TT: adjusted OR=1.580, 95% CI=1.106– 2.259, P=0.012) and male (CC/CT vs TT: adjusted OR=1.653, 95% CI=1.101– 2.481, P=0.015) KD patients.Conclusion: The results of this study demonstrated that the FNDC1 rs3003174 C>T polymorphism may be a hazard factor in the formation of CAA in KD patients that was not disclosed before.Keywords: coronary artery aneurysm, Kawasaki disease, fibronectin type III domain containing 1, polymorphisms |
| format |
article |
| author |
Lin K Zhang L Wang Y Li J Xu Y Che D Mai H Yu H Fu L Wei B Jiang Z Pi L Gu X |
| author_facet |
Lin K Zhang L Wang Y Li J Xu Y Che D Mai H Yu H Fu L Wei B Jiang Z Pi L Gu X |
| author_sort |
Lin K |
| title |
FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population |
| title_short |
FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population |
| title_full |
FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population |
| title_fullStr |
FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population |
| title_full_unstemmed |
FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population |
| title_sort |
fndc1 polymorphism (rs3003174 c > t) increased the incidence of coronary artery aneurysm in patients with kawasaki disease in a southern chinese population |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/d28746bb14644da8a44949bb66180a5b |
| work_keys_str_mv |
AT link fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT zhangl fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT wangy fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT lij fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT xuy fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT ched fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT maih fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT yuh fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT ful fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT weib fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT jiangz fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT pil fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation AT gux fndc1polymorphismrs3003174cgttincreasedtheincidenceofcoronaryarteryaneurysminpatientswithkawasakidiseaseinasouthernchinesepopulation |
| _version_ |
1718379671601545216 |