Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis

Abstract Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990’s for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different resp...

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Autores principales:	Dylan Henssen, Erkan Kurt, Anne-Marie Van Cappellen van Walsum, Tamas Kozicz, Robert van Dongen, Ronald Bartels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d289911f293f4285a69ea497f79ff91f
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spelling	oai:doaj.org-article:d289911f293f4285a69ea497f79ff91f2021-12-02T17:14:59ZMotor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis10.1038/s41598-020-64177-z2045-2322https://doaj.org/article/d289911f293f4285a69ea497f79ff91f2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-64177-zhttps://doaj.org/toc/2045-2322Abstract Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990’s for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, this paper investigated (1) whether the effectiveness of iMCS is significantly different among different CNOP disorders and (2) whether other confounding factors can be impacting iMCS results in CNOP. A systematic review and meta-analysis using a linear mixed-model was performed. Twenty-three papers were included, totaling 140 CNOP patients. Heterogeneity of the studies showed to be 55.8%. A visual analogue scale (VAS) measured median pain relief of 66.5% (ranging from 0–100%) was found. Linear mixed-model analysis showed that patients suffering from trigeminal neuralgia responded significantly more favorable to iMCS than patients suffering from dysfunctional pain syndromes (p = 0.030). Also, patients suffering from CNOP caused by (supra)nuclear lesions responded marginally significantly better to iMCS than patients suffering from CNOP due to trigeminal nerve lesions (p = 0.049). No other confounding factors were elucidated. This meta-analysis showed that patients suffering from trigeminal neuralgia and patients suffering from (supra)nuclear lesions causing CNOP responded significantly more favorable than others on iMCS. No other confounding factors were found relevant.Dylan HenssenErkan KurtAnne-Marie Van Cappellen van WalsumTamas KoziczRobert van DongenRonald BartelsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dylan Henssen Erkan Kurt Anne-Marie Van Cappellen van Walsum Tamas Kozicz Robert van Dongen Ronald Bartels Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis
description	Abstract Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990’s for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, this paper investigated (1) whether the effectiveness of iMCS is significantly different among different CNOP disorders and (2) whether other confounding factors can be impacting iMCS results in CNOP. A systematic review and meta-analysis using a linear mixed-model was performed. Twenty-three papers were included, totaling 140 CNOP patients. Heterogeneity of the studies showed to be 55.8%. A visual analogue scale (VAS) measured median pain relief of 66.5% (ranging from 0–100%) was found. Linear mixed-model analysis showed that patients suffering from trigeminal neuralgia responded significantly more favorable to iMCS than patients suffering from dysfunctional pain syndromes (p = 0.030). Also, patients suffering from CNOP caused by (supra)nuclear lesions responded marginally significantly better to iMCS than patients suffering from CNOP due to trigeminal nerve lesions (p = 0.049). No other confounding factors were elucidated. This meta-analysis showed that patients suffering from trigeminal neuralgia and patients suffering from (supra)nuclear lesions causing CNOP responded significantly more favorable than others on iMCS. No other confounding factors were found relevant.
format	article
author	Dylan Henssen Erkan Kurt Anne-Marie Van Cappellen van Walsum Tamas Kozicz Robert van Dongen Ronald Bartels
author_facet	Dylan Henssen Erkan Kurt Anne-Marie Van Cappellen van Walsum Tamas Kozicz Robert van Dongen Ronald Bartels
author_sort	Dylan Henssen
title	Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis
title_short	Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis
title_full	Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis
title_fullStr	Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis
title_full_unstemmed	Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis
title_sort	motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d289911f293f4285a69ea497f79ff91f
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Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis

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