Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage

Qian Xu, Yi-ting Wei, Shuang-bo Fan, Liang Wang, Xiao-ping Zhou Department of Brain Surgery, Ningbo Zhenhai Longsai Hospital, Zhejiang, People’s Republic of China Aim: The role of hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke is controversial. This study aims...

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Autores principales:	Xu Q, Wei Y, Fan S, Wang L, Zhou XP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Hyperbaric oxygen therapy type 2 diabetes intracerebral hemorrhage NIHSS glucose infusion rate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d28a465d837a4fec92be880309bc4098
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spelling	oai:doaj.org-article:d28a465d837a4fec92be880309bc40982021-12-02T05:00:36ZRepetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage1178-2021https://doaj.org/article/d28a465d837a4fec92be880309bc40982017-02-01T00:00:00Zhttps://www.dovepress.com/repetitive-hyperbaric-oxygen-treatment-increases-insulin-sensitivity-i-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Qian Xu, Yi-ting Wei, Shuang-bo Fan, Liang Wang, Xiao-ping Zhou Department of Brain Surgery, Ningbo Zhenhai Longsai Hospital, Zhejiang, People’s Republic of China Aim: The role of hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke is controversial. This study aims to investigate whether the peripheral insulin sensitivity of type 2 diabetes patients suffering from intracerebral hemorrhage can be increased after HBOT.Methods: Fifty-two type 2 diabetes participants were recruited after being diagnosed with intracerebral hemorrhage in our hospital. Insulin sensitivity was measured by the glucose infusion rate during a hyperinsulinemic euglycemic clamp (80 mU m-2 min-1) at baseline and 10 and 30 days after HBOT sessions. Serum insulin, fasting glucose, and hemoglobin A1C were measured in fasting serum at baseline and after HBOT sessions. In addition, early (~10 days after onset) and late (1 month after onset) outcomes (National Institutes of Health Stroke Scale, NIHSS scores) and efficacy (changes of NIHSS scores) of HBOT were evaluated.Results: In response to HBOT, the glucose infusion rate was increased by 37.8%±5.76% at 1 month after onset compared with baseline. Reduced serum insulin, fasting glucose, and hemoglobin A1C were observed after HBOT. Both early and late outcomes of the HBOT group were improved compared with baseline (P<0.001). In the control group, there was significant difference only in the late outcome (P<0.05). In the assessment of efficacy, there were statistically significant differences between the groups when comparing changes in NIHSS scores at 10 days and 1 month after onset (P<0.05).Conclusion: Peripheral insulin sensitivity was increased following HBOT in type 2 diabetes patients with intracerebral hemorrhage. The HBOT used in this study may be effective for diabetes patients with acute stroke and is a safe and harmless adjunctive treatment. Keywords: hyperbaric oxygen therapy, type 2 diabetes, intracerebral hemorrhage, NIHSS, glucose infusion rateXu QWei YFan SWang LZhou XPDove Medical PressarticleHyperbaric oxygen therapytype 2 diabetesintracerebral hemorrhageNIHSSglucose infusion rateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 421-426 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hyperbaric oxygen therapy type 2 diabetes intracerebral hemorrhage NIHSS glucose infusion rate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Hyperbaric oxygen therapy type 2 diabetes intracerebral hemorrhage NIHSS glucose infusion rate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu Q Wei Y Fan S Wang L Zhou XP Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage
description	Qian Xu, Yi-ting Wei, Shuang-bo Fan, Liang Wang, Xiao-ping Zhou Department of Brain Surgery, Ningbo Zhenhai Longsai Hospital, Zhejiang, People’s Republic of China Aim: The role of hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke is controversial. This study aims to investigate whether the peripheral insulin sensitivity of type 2 diabetes patients suffering from intracerebral hemorrhage can be increased after HBOT.Methods: Fifty-two type 2 diabetes participants were recruited after being diagnosed with intracerebral hemorrhage in our hospital. Insulin sensitivity was measured by the glucose infusion rate during a hyperinsulinemic euglycemic clamp (80 mU m-2 min-1) at baseline and 10 and 30 days after HBOT sessions. Serum insulin, fasting glucose, and hemoglobin A1C were measured in fasting serum at baseline and after HBOT sessions. In addition, early (~10 days after onset) and late (1 month after onset) outcomes (National Institutes of Health Stroke Scale, NIHSS scores) and efficacy (changes of NIHSS scores) of HBOT were evaluated.Results: In response to HBOT, the glucose infusion rate was increased by 37.8%±5.76% at 1 month after onset compared with baseline. Reduced serum insulin, fasting glucose, and hemoglobin A1C were observed after HBOT. Both early and late outcomes of the HBOT group were improved compared with baseline (P<0.001). In the control group, there was significant difference only in the late outcome (P<0.05). In the assessment of efficacy, there were statistically significant differences between the groups when comparing changes in NIHSS scores at 10 days and 1 month after onset (P<0.05).Conclusion: Peripheral insulin sensitivity was increased following HBOT in type 2 diabetes patients with intracerebral hemorrhage. The HBOT used in this study may be effective for diabetes patients with acute stroke and is a safe and harmless adjunctive treatment. Keywords: hyperbaric oxygen therapy, type 2 diabetes, intracerebral hemorrhage, NIHSS, glucose infusion rate
format	article
author	Xu Q Wei Y Fan S Wang L Zhou XP
author_facet	Xu Q Wei Y Fan S Wang L Zhou XP
author_sort	Xu Q
title	Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage
title_short	Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage
title_full	Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage
title_fullStr	Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage
title_full_unstemmed	Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage
title_sort	repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d28a465d837a4fec92be880309bc4098
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_version_	1718400856642027520

Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage

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