Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study

Abstract The use of phosphate (P)-binders allows hemodialysis patients to take in more protein and thus may maintain a good nutritional status. Protein-energy-malnutrition increases the risk of infection-related death. The association between use of P-binders and the relative risks of infection-rela...

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Autores principales: Shunsuke Yamada, Masanori Tokumoto, Masatomo Taniguchi, Hisako Yoshida, Hokuto Arase, Narihito Tatsumoto, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya
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Publicado: Nature Portfolio 2018
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spelling oai:doaj.org-article:d28e5f207a7b4dafa65296d34a2dd25a2021-12-02T15:08:25ZUse of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study10.1038/s41598-018-29757-02045-2322https://doaj.org/article/d28e5f207a7b4dafa65296d34a2dd25a2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29757-0https://doaj.org/toc/2045-2322Abstract The use of phosphate (P)-binders allows hemodialysis patients to take in more protein and thus may maintain a good nutritional status. Protein-energy-malnutrition increases the risk of infection-related death. The association between use of P-binders and the relative risks of infection-related death remains unknown in hemodialysis patients. A total of 2926 hemodialysis patients registered to the Q-Cohort Study was followed up for 4-years. The association between use of P-binders and the risks for infection-related and all-cause mortality were estimated by Cox proportional hazards risk model with multiple adjustments by conventional and propensity-score based approaches. During the follow-up period, 106 patients and 492 patients died of infection and any cause, respectively. Cox proportional hazards models with multivariable adjustments including nutritional confounders showed that the incidence of infection-related death was significantly lower in patients with P-binders use compared with those without (hazard ratio [95% confidence interval] for infection-related mortality 0.63 [0.40–0.99]). The results remained significant even after applying four different propensity score-based analyses. Notably, use of P-binders was associated with a lower risk of all-cause mortality. Further studies including randomized controlled clinical trials and observational studies analyzed by an instrumental variable model will provide more robust evidences for the associations observed in our study.Shunsuke YamadaMasanori TokumotoMasatomo TaniguchiHisako YoshidaHokuto AraseNarihito TatsumotoHideki HirakataTakanari KitazonoKazuhiko TsuruyaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shunsuke Yamada
Masanori Tokumoto
Masatomo Taniguchi
Hisako Yoshida
Hokuto Arase
Narihito Tatsumoto
Hideki Hirakata
Takanari Kitazono
Kazuhiko Tsuruya
Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study
description Abstract The use of phosphate (P)-binders allows hemodialysis patients to take in more protein and thus may maintain a good nutritional status. Protein-energy-malnutrition increases the risk of infection-related death. The association between use of P-binders and the relative risks of infection-related death remains unknown in hemodialysis patients. A total of 2926 hemodialysis patients registered to the Q-Cohort Study was followed up for 4-years. The association between use of P-binders and the risks for infection-related and all-cause mortality were estimated by Cox proportional hazards risk model with multiple adjustments by conventional and propensity-score based approaches. During the follow-up period, 106 patients and 492 patients died of infection and any cause, respectively. Cox proportional hazards models with multivariable adjustments including nutritional confounders showed that the incidence of infection-related death was significantly lower in patients with P-binders use compared with those without (hazard ratio [95% confidence interval] for infection-related mortality 0.63 [0.40–0.99]). The results remained significant even after applying four different propensity score-based analyses. Notably, use of P-binders was associated with a lower risk of all-cause mortality. Further studies including randomized controlled clinical trials and observational studies analyzed by an instrumental variable model will provide more robust evidences for the associations observed in our study.
format article
author Shunsuke Yamada
Masanori Tokumoto
Masatomo Taniguchi
Hisako Yoshida
Hokuto Arase
Narihito Tatsumoto
Hideki Hirakata
Takanari Kitazono
Kazuhiko Tsuruya
author_facet Shunsuke Yamada
Masanori Tokumoto
Masatomo Taniguchi
Hisako Yoshida
Hokuto Arase
Narihito Tatsumoto
Hideki Hirakata
Takanari Kitazono
Kazuhiko Tsuruya
author_sort Shunsuke Yamada
title Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study
title_short Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study
title_full Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study
title_fullStr Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study
title_full_unstemmed Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study
title_sort use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: the q-cohort study
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d28e5f207a7b4dafa65296d34a2dd25a
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