Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection

Phenotypically tolerant, persister bacterial subpopulations can survive transient antibiotic treatment and facilitate resistance evolution. Here, Nordholt et al. show that E. coli can display persistence against a widely used disinfectant and this is associated with alterations in the cell surface a...

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Autores principales:	Niclas Nordholt, Orestis Kanaris, Selina B. I. Schmidt, Frank Schreiber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d28feceec5e440e6a3aacfd2811aa663
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spelling	oai:doaj.org-article:d28feceec5e440e6a3aacfd2811aa6632021-11-28T12:32:08ZPersistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection10.1038/s41467-021-27019-82041-1723https://doaj.org/article/d28feceec5e440e6a3aacfd2811aa6632021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27019-8https://doaj.org/toc/2041-1723Phenotypically tolerant, persister bacterial subpopulations can survive transient antibiotic treatment and facilitate resistance evolution. Here, Nordholt et al. show that E. coli can display persistence against a widely used disinfectant and this is associated with alterations in the cell surface and with antibiotic tolerance.Niclas NordholtOrestis KanarisSelina B. I. SchmidtFrank SchreiberNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niclas Nordholt Orestis Kanaris Selina B. I. Schmidt Frank Schreiber Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection
description	Phenotypically tolerant, persister bacterial subpopulations can survive transient antibiotic treatment and facilitate resistance evolution. Here, Nordholt et al. show that E. coli can display persistence against a widely used disinfectant and this is associated with alterations in the cell surface and with antibiotic tolerance.
format	article
author	Niclas Nordholt Orestis Kanaris Selina B. I. Schmidt Frank Schreiber
author_facet	Niclas Nordholt Orestis Kanaris Selina B. I. Schmidt Frank Schreiber
author_sort	Niclas Nordholt
title	Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection
title_short	Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection
title_full	Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection
title_fullStr	Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection
title_full_unstemmed	Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection
title_sort	persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d28feceec5e440e6a3aacfd2811aa663
work_keys_str_mv	AT niclasnordholt persistenceagainstbenzalkoniumchloridepromotesrapidevolutionoftoleranceduringperiodicdisinfection AT orestiskanaris persistenceagainstbenzalkoniumchloridepromotesrapidevolutionoftoleranceduringperiodicdisinfection AT selinabischmidt persistenceagainstbenzalkoniumchloridepromotesrapidevolutionoftoleranceduringperiodicdisinfection AT frankschreiber persistenceagainstbenzalkoniumchloridepromotesrapidevolutionoftoleranceduringperiodicdisinfection
_version_	1718407922610864128

Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection

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