Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?

The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix...

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Autores principales:	Madhan Jeyaraman, Sathish Muthu, Prakash Gangadaran, Rajni Ranjan, Naveen Jeyaraman, Gollahalli Shivashankar Prajwal, Prabhu Chandra Mishra, Ramya Lakshmi Rajendran, Byeong-Cheol Ahn
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	periosteum mesenchymal stromal cells chondrogenesis osteogenesis Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d294a541ec8148c184db7a2d2a201765
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spelling	oai:doaj.org-article:d294a541ec8148c184db7a2d2a2017652021-11-25T18:39:36ZOsteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?10.3390/ph141111331424-8247https://doaj.org/article/d294a541ec8148c184db7a2d2a2017652021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1133https://doaj.org/toc/1424-8247The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future.Madhan JeyaramanSathish MuthuPrakash GangadaranRajni RanjanNaveen JeyaramanGollahalli Shivashankar PrajwalPrabhu Chandra MishraRamya Lakshmi RajendranByeong-Cheol AhnMDPI AGarticleperiosteummesenchymal stromal cellschondrogenesisosteogenesisMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1133, p 1133 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	periosteum mesenchymal stromal cells chondrogenesis osteogenesis Medicine R Pharmacy and materia medica RS1-441
spellingShingle	periosteum mesenchymal stromal cells chondrogenesis osteogenesis Medicine R Pharmacy and materia medica RS1-441 Madhan Jeyaraman Sathish Muthu Prakash Gangadaran Rajni Ranjan Naveen Jeyaraman Gollahalli Shivashankar Prajwal Prabhu Chandra Mishra Ramya Lakshmi Rajendran Byeong-Cheol Ahn Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
description	The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future.
format	article
author	Madhan Jeyaraman Sathish Muthu Prakash Gangadaran Rajni Ranjan Naveen Jeyaraman Gollahalli Shivashankar Prajwal Prabhu Chandra Mishra Ramya Lakshmi Rajendran Byeong-Cheol Ahn
author_facet	Madhan Jeyaraman Sathish Muthu Prakash Gangadaran Rajni Ranjan Naveen Jeyaraman Gollahalli Shivashankar Prajwal Prabhu Chandra Mishra Ramya Lakshmi Rajendran Byeong-Cheol Ahn
author_sort	Madhan Jeyaraman
title	Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_short	Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_full	Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_fullStr	Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_full_unstemmed	Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_sort	osteogenic and chondrogenic potential of periosteum-derived mesenchymal stromal cells: do they hold the key to the future?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d294a541ec8148c184db7a2d2a201765
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Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?

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