Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landscape of 32 RIGs cases.

Guardado en:
Detalles Bibliográficos
Autores principales: Maximilian Y. Deng, Dominik Sturm, Elke Pfaff, Martin Sill, Damian Stichel, Gnana Prakash Balasubramanian, Stephan Tippelt, Christof Kramm, Andrew M. Donson, Adam L. Green, Chris Jones, Jens Schittenhelm, Martin Ebinger, Martin U. Schuhmann, Barbara C. Jones, Cornelis M. van Tilburg, Andrea Wittmann, Andrey Golanov, Marina Ryzhova, Jonas Ecker, Till Milde, Olaf Witt, Felix Sahm, David Reuss, David Sumerauer, Josef Zamecnik, Andrey Korshunov, Andreas von Deimling, Stefan M. Pfister, David T. W. Jones
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d294b00cf8014bf897f67d7d3d39f257
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d294b00cf8014bf897f67d7d3d39f257
record_format dspace
spelling oai:doaj.org-article:d294b00cf8014bf897f67d7d3d39f2572021-12-02T17:27:20ZRadiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B10.1038/s41467-021-25708-y2041-1723https://doaj.org/article/d294b00cf8014bf897f67d7d3d39f2572021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25708-yhttps://doaj.org/toc/2041-1723Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landscape of 32 RIGs cases.Maximilian Y. DengDominik SturmElke PfaffMartin SillDamian StichelGnana Prakash BalasubramanianStephan TippeltChristof KrammAndrew M. DonsonAdam L. GreenChris JonesJens SchittenhelmMartin EbingerMartin U. SchuhmannBarbara C. JonesCornelis M. van TilburgAndrea WittmannAndrey GolanovMarina RyzhovaJonas EckerTill MildeOlaf WittFelix SahmDavid ReussDavid SumerauerJosef ZamecnikAndrey KorshunovAndreas von DeimlingStefan M. PfisterDavid T. W. JonesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maximilian Y. Deng
Dominik Sturm
Elke Pfaff
Martin Sill
Damian Stichel
Gnana Prakash Balasubramanian
Stephan Tippelt
Christof Kramm
Andrew M. Donson
Adam L. Green
Chris Jones
Jens Schittenhelm
Martin Ebinger
Martin U. Schuhmann
Barbara C. Jones
Cornelis M. van Tilburg
Andrea Wittmann
Andrey Golanov
Marina Ryzhova
Jonas Ecker
Till Milde
Olaf Witt
Felix Sahm
David Reuss
David Sumerauer
Josef Zamecnik
Andrey Korshunov
Andreas von Deimling
Stefan M. Pfister
David T. W. Jones
Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
description Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landscape of 32 RIGs cases.
format article
author Maximilian Y. Deng
Dominik Sturm
Elke Pfaff
Martin Sill
Damian Stichel
Gnana Prakash Balasubramanian
Stephan Tippelt
Christof Kramm
Andrew M. Donson
Adam L. Green
Chris Jones
Jens Schittenhelm
Martin Ebinger
Martin U. Schuhmann
Barbara C. Jones
Cornelis M. van Tilburg
Andrea Wittmann
Andrey Golanov
Marina Ryzhova
Jonas Ecker
Till Milde
Olaf Witt
Felix Sahm
David Reuss
David Sumerauer
Josef Zamecnik
Andrey Korshunov
Andreas von Deimling
Stefan M. Pfister
David T. W. Jones
author_facet Maximilian Y. Deng
Dominik Sturm
Elke Pfaff
Martin Sill
Damian Stichel
Gnana Prakash Balasubramanian
Stephan Tippelt
Christof Kramm
Andrew M. Donson
Adam L. Green
Chris Jones
Jens Schittenhelm
Martin Ebinger
Martin U. Schuhmann
Barbara C. Jones
Cornelis M. van Tilburg
Andrea Wittmann
Andrey Golanov
Marina Ryzhova
Jonas Ecker
Till Milde
Olaf Witt
Felix Sahm
David Reuss
David Sumerauer
Josef Zamecnik
Andrey Korshunov
Andreas von Deimling
Stefan M. Pfister
David T. W. Jones
author_sort Maximilian Y. Deng
title Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
title_short Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
title_full Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
title_fullStr Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
title_full_unstemmed Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
title_sort radiation-induced gliomas represent h3-/idh-wild type pediatric gliomas with recurrent pdgfra amplification and loss of cdkn2a/b
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d294b00cf8014bf897f67d7d3d39f257
work_keys_str_mv AT maximilianydeng radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT dominiksturm radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT elkepfaff radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT martinsill radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT damianstichel radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT gnanaprakashbalasubramanian radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT stephantippelt radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT christofkramm radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT andrewmdonson radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT adamlgreen radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT chrisjones radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT jensschittenhelm radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT martinebinger radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT martinuschuhmann radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT barbaracjones radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT cornelismvantilburg radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT andreawittmann radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT andreygolanov radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT marinaryzhova radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT jonasecker radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT tillmilde radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT olafwitt radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT felixsahm radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT davidreuss radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT davidsumerauer radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT josefzamecnik radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT andreykorshunov radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT andreasvondeimling radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT stefanmpfister radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
AT davidtwjones radiationinducedgliomasrepresenth3idhwildtypepediatricgliomaswithrecurrentpdgfraamplificationandlossofcdkn2ab
_version_ 1718380815238299648

Ejemplares similares