Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse tumorigesis on its own, acting through a RAS/MYC...

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Autores principales: Sanja Pajovic, Robert Siddaway, Taylor Bridge, Javal Sheth, Patricia Rakopoulos, Byungjin Kim, Scott Ryall, Sameer Agnihotri, Lauren Phillips, Man Yu, Christopher Li, Scott Milos, Palak Patel, Dilakshan Srikanthan, Annie Huang, Cynthia Hawkins
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d2950e03eca24abe9198eff022010cfc
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spelling oai:doaj.org-article:d2950e03eca24abe9198eff022010cfc2021-12-02T15:39:16ZEpigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer10.1038/s41467-020-19972-72041-1723https://doaj.org/article/d2950e03eca24abe9198eff022010cfc2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19972-7https://doaj.org/toc/2041-1723Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse tumorigesis on its own, acting through a RAS/MYC transcriptomic programme.Sanja PajovicRobert SiddawayTaylor BridgeJaval ShethPatricia RakopoulosByungjin KimScott RyallSameer AgnihotriLauren PhillipsMan YuChristopher LiScott MilosPalak PatelDilakshan SrikanthanAnnie HuangCynthia HawkinsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sanja Pajovic
Robert Siddaway
Taylor Bridge
Javal Sheth
Patricia Rakopoulos
Byungjin Kim
Scott Ryall
Sameer Agnihotri
Lauren Phillips
Man Yu
Christopher Li
Scott Milos
Palak Patel
Dilakshan Srikanthan
Annie Huang
Cynthia Hawkins
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
description Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse tumorigesis on its own, acting through a RAS/MYC transcriptomic programme.
format article
author Sanja Pajovic
Robert Siddaway
Taylor Bridge
Javal Sheth
Patricia Rakopoulos
Byungjin Kim
Scott Ryall
Sameer Agnihotri
Lauren Phillips
Man Yu
Christopher Li
Scott Milos
Palak Patel
Dilakshan Srikanthan
Annie Huang
Cynthia Hawkins
author_facet Sanja Pajovic
Robert Siddaway
Taylor Bridge
Javal Sheth
Patricia Rakopoulos
Byungjin Kim
Scott Ryall
Sameer Agnihotri
Lauren Phillips
Man Yu
Christopher Li
Scott Milos
Palak Patel
Dilakshan Srikanthan
Annie Huang
Cynthia Hawkins
author_sort Sanja Pajovic
title Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
title_short Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
title_full Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
title_fullStr Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
title_full_unstemmed Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
title_sort epigenetic activation of a ras/myc axis in h3.3k27m-driven cancer
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d2950e03eca24abe9198eff022010cfc
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