Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory

Abstract Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic cortex for their role in mediating contextual fear, a form of associative memory. K...

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Autores principales:	Nadine F. Joseph, Aya Zucca, Jenna L. Wingfield, Isabel Espadas, Damon Page, Sathyanarayanan V. Puthanveettil
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Kinesins Contextual fear memory Extinction Dendritic spines Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d2983862208b4be4bb6b9ada8da8de19
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spelling	oai:doaj.org-article:d2983862208b4be4bb6b9ada8da8de192021-11-14T12:42:36ZMolecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory10.1186/s13041-021-00873-91756-6606https://doaj.org/article/d2983862208b4be4bb6b9ada8da8de192021-11-01T00:00:00Zhttps://doi.org/10.1186/s13041-021-00873-9https://doaj.org/toc/1756-6606Abstract Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic cortex for their role in mediating contextual fear, a form of associative memory. KIFs function as critical mediators of synaptic transmission and plasticity by their ability to modulate microtubule function and transport of gene products. However, the regulation and function of KIFs in the prelimbic cortex insofar as mediating memory consolidation is not known. We find that within one hour of contextual fear conditioning, the expression of KIF3B is upregulated in the prelimbic but not the infralimbic cortex. Importantly, lentiviral-mediated knockdown of KIF3B in the prelimbic cortex produces deficits in consolidation while reducing freezing behavior during extinction of contextual fear. We also find that the depletion of KIF3B increases spine density within prelimbic neurons. Taken together, these results illuminate a key role for KIF3B in the prelimbic cortex as far as mediating contextual fear memory.Nadine F. JosephAya ZuccaJenna L. WingfieldIsabel EspadasDamon PageSathyanarayanan V. PuthanveettilBMCarticleKinesinsContextual fear memoryExtinctionDendritic spinesNeurology. Diseases of the nervous systemRC346-429ENMolecular Brain, Vol 14, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Kinesins Contextual fear memory Extinction Dendritic spines Neurology. Diseases of the nervous system RC346-429
spellingShingle	Kinesins Contextual fear memory Extinction Dendritic spines Neurology. Diseases of the nervous system RC346-429 Nadine F. Joseph Aya Zucca Jenna L. Wingfield Isabel Espadas Damon Page Sathyanarayanan V. Puthanveettil Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
description	Abstract Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic cortex for their role in mediating contextual fear, a form of associative memory. KIFs function as critical mediators of synaptic transmission and plasticity by their ability to modulate microtubule function and transport of gene products. However, the regulation and function of KIFs in the prelimbic cortex insofar as mediating memory consolidation is not known. We find that within one hour of contextual fear conditioning, the expression of KIF3B is upregulated in the prelimbic but not the infralimbic cortex. Importantly, lentiviral-mediated knockdown of KIF3B in the prelimbic cortex produces deficits in consolidation while reducing freezing behavior during extinction of contextual fear. We also find that the depletion of KIF3B increases spine density within prelimbic neurons. Taken together, these results illuminate a key role for KIF3B in the prelimbic cortex as far as mediating contextual fear memory.
format	article
author	Nadine F. Joseph Aya Zucca Jenna L. Wingfield Isabel Espadas Damon Page Sathyanarayanan V. Puthanveettil
author_facet	Nadine F. Joseph Aya Zucca Jenna L. Wingfield Isabel Espadas Damon Page Sathyanarayanan V. Puthanveettil
author_sort	Nadine F. Joseph
title	Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
title_short	Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
title_full	Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
title_fullStr	Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
title_full_unstemmed	Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
title_sort	molecular motor kif3b in the prelimbic cortex constrains the consolidation of contextual fear memory
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d2983862208b4be4bb6b9ada8da8de19
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Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory

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