TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes

Many neurodegenerative disorders are characterised by the accumulation of protein aggregates in neurons. Here, the authors show that the lysosomal protein TECPR1 selectively recruits mature autophagosomes via an interaction with LC3C to break down protein aggregates in neural stem cells.

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Autores principales:	Lisa Wetzel, Stéphane Blanchard, Sowmya Rama, Viola Beier, Anna Kaufmann, Thomas Wollert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d29a27c14ad747c795c581cc170d175d
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spelling	oai:doaj.org-article:d29a27c14ad747c795c581cc170d175d2021-12-02T17:30:39ZTECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes10.1038/s41467-020-16689-52041-1723https://doaj.org/article/d29a27c14ad747c795c581cc170d175d2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16689-5https://doaj.org/toc/2041-1723Many neurodegenerative disorders are characterised by the accumulation of protein aggregates in neurons. Here, the authors show that the lysosomal protein TECPR1 selectively recruits mature autophagosomes via an interaction with LC3C to break down protein aggregates in neural stem cells.Lisa WetzelStéphane BlanchardSowmya RamaViola BeierAnna KaufmannThomas WollertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lisa Wetzel Stéphane Blanchard Sowmya Rama Viola Beier Anna Kaufmann Thomas Wollert TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
description	Many neurodegenerative disorders are characterised by the accumulation of protein aggregates in neurons. Here, the authors show that the lysosomal protein TECPR1 selectively recruits mature autophagosomes via an interaction with LC3C to break down protein aggregates in neural stem cells.
format	article
author	Lisa Wetzel Stéphane Blanchard Sowmya Rama Viola Beier Anna Kaufmann Thomas Wollert
author_facet	Lisa Wetzel Stéphane Blanchard Sowmya Rama Viola Beier Anna Kaufmann Thomas Wollert
author_sort	Lisa Wetzel
title	TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
title_short	TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
title_full	TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
title_fullStr	TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
title_full_unstemmed	TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
title_sort	tecpr1 promotes aggrephagy by direct recruitment of lc3c autophagosomes to lysosomes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d29a27c14ad747c795c581cc170d175d
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TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes

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