M-DATA: A statistical approach to jointly analyzing de novo mutations for multiple traits

Recent studies have demonstrated that multiple early-onset diseases have shared risk genes, based on findings from de novo mutations (DNMs). Therefore, we may leverage information from one trait to improve statistical power to identify genes for another trait. However, there are few methods that can...

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Autores principales: Yuhan Xie, Mo Li, Weilai Dong, Wei Jiang, Hongyu Zhao
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/d29dcddfbd6d4497a13588ad6a03a51c
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