Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment

Binita Shrestha,1 Lijun Wang,1 Hao Zhang,2 Chiung Yu Hung,2 Liang Tang1 1Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA; 2Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USACorrespondence: Liang TangDepartment of Bio...

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Autores principales:	Shrestha B, Wang L, Zhang H, Hung CY, Tang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanomedicine cancer therapy ph-responsive co-delivery plk1 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d29e140b39684adabce71c5e6744546a
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spelling	oai:doaj.org-article:d29e140b39684adabce71c5e6744546a2021-12-02T12:31:06ZGold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment1178-2013https://doaj.org/article/d29e140b39684adabce71c5e6744546a2020-10-01T00:00:00Zhttps://www.dovepress.com/gold-nanoparticles-mediated-drug-gene-combinational-therapy-for-breast-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Binita Shrestha,1 Lijun Wang,1 Hao Zhang,2 Chiung Yu Hung,2 Liang Tang1 1Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA; 2Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USACorrespondence: Liang TangDepartment of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USATel +1 210-458-7995Email Liang.Tang@utsa.eduBackground: Cancer is a complex heterogeneous disease to which singular modes of treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular pathways using combinational therapies has been gaining popularity in cancer treatment, with the added benefit of reducing dosage and side effects.Methods: A gold nanoparticle-mediated drug delivery nanoplatform was developed for co-delivery of doxorubicin and polo-like kinase 1 (PLK1) siRNA. Gold nanoparticles were coated with polyethyleneimine to facilitate assembly of PLK1 on the surface. Doxorubicin was loaded on nanoparticles through a pH-sensitive linker with a thiol group at one terminal end for controlled release.Results: The therapeutic efficiency of this co-delivery system was evaluated in 2D and 3D cultured systems. The reduced IC50 value clearly demonstrated the synergistic effect of combined drug and gene delivery over their individual delivery in a cancer treatment model.Conclusion: This study may provide an adaptable, facile platform to investigate drug-siRNA combinations for cancer inhibition.Keywords: nanomedicine, cancer therapy, pH-responsive, co-delivery, PLK1Shrestha BWang LZhang HHung CYTang LDove Medical Pressarticlenanomedicinecancer therapyph-responsiveco-deliveryplk1Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8109-8119 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomedicine cancer therapy ph-responsive co-delivery plk1 Medicine (General) R5-920
spellingShingle	nanomedicine cancer therapy ph-responsive co-delivery plk1 Medicine (General) R5-920 Shrestha B Wang L Zhang H Hung CY Tang L Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment
description	Binita Shrestha,1 Lijun Wang,1 Hao Zhang,2 Chiung Yu Hung,2 Liang Tang1 1Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA; 2Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USACorrespondence: Liang TangDepartment of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USATel +1 210-458-7995Email Liang.Tang@utsa.eduBackground: Cancer is a complex heterogeneous disease to which singular modes of treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular pathways using combinational therapies has been gaining popularity in cancer treatment, with the added benefit of reducing dosage and side effects.Methods: A gold nanoparticle-mediated drug delivery nanoplatform was developed for co-delivery of doxorubicin and polo-like kinase 1 (PLK1) siRNA. Gold nanoparticles were coated with polyethyleneimine to facilitate assembly of PLK1 on the surface. Doxorubicin was loaded on nanoparticles through a pH-sensitive linker with a thiol group at one terminal end for controlled release.Results: The therapeutic efficiency of this co-delivery system was evaluated in 2D and 3D cultured systems. The reduced IC50 value clearly demonstrated the synergistic effect of combined drug and gene delivery over their individual delivery in a cancer treatment model.Conclusion: This study may provide an adaptable, facile platform to investigate drug-siRNA combinations for cancer inhibition.Keywords: nanomedicine, cancer therapy, pH-responsive, co-delivery, PLK1
format	article
author	Shrestha B Wang L Zhang H Hung CY Tang L
author_facet	Shrestha B Wang L Zhang H Hung CY Tang L
author_sort	Shrestha B
title	Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment
title_short	Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment
title_full	Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment
title_fullStr	Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment
title_full_unstemmed	Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment
title_sort	gold nanoparticles mediated drug-gene combinational therapy for breast cancer treatment
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d29e140b39684adabce71c5e6744546a
work_keys_str_mv	AT shresthab goldnanoparticlesmediateddruggenecombinationaltherapyforbreastcancertreatment AT wangl goldnanoparticlesmediateddruggenecombinationaltherapyforbreastcancertreatment AT zhangh goldnanoparticlesmediateddruggenecombinationaltherapyforbreastcancertreatment AT hungcy goldnanoparticlesmediateddruggenecombinationaltherapyforbreastcancertreatment AT tangl goldnanoparticlesmediateddruggenecombinationaltherapyforbreastcancertreatment
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Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment

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