Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.

Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited data have so far demonstrated the critical st...

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Autores principales: Caroline B Madsen, Kirstine Lavrsen, Catharina Steentoft, Malene B Vester-Christensen, Henrik Clausen, Hans H Wandall, Anders Elm Pedersen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/d29f6a412dca4efc8e46d49fbb687bc5
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