Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

Treg cells suppress peripheral immune responses, but their function in haematopoiesis is unclear. Here the authors show they modulate the bone marrow microenvironment to sustain haematopoietic stem cell-driven generation of mature B cells.

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Autores principales: Antonio Pierini, Hidekazu Nishikii, Jeanette Baker, Takaharu Kimura, Hye-Sook Kwon, Yuqiong Pan, Yan Chen, Maite Alvarez, William Strober, Andrea Velardi, Judith A. Shizuru, Joy Y. Wu, Shigeru Chiba, Robert S. Negrin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/d29f840a46334d1d870fa58393c51f4b
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spelling oai:doaj.org-article:d29f840a46334d1d870fa58393c51f4b2021-12-02T15:38:54ZFoxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis10.1038/ncomms150682041-1723https://doaj.org/article/d29f840a46334d1d870fa58393c51f4b2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15068https://doaj.org/toc/2041-1723Treg cells suppress peripheral immune responses, but their function in haematopoiesis is unclear. Here the authors show they modulate the bone marrow microenvironment to sustain haematopoietic stem cell-driven generation of mature B cells.Antonio PieriniHidekazu NishikiiJeanette BakerTakaharu KimuraHye-Sook KwonYuqiong PanYan ChenMaite AlvarezWilliam StroberAndrea VelardiJudith A. ShizuruJoy Y. WuShigeru ChibaRobert S. NegrinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Antonio Pierini
Hidekazu Nishikii
Jeanette Baker
Takaharu Kimura
Hye-Sook Kwon
Yuqiong Pan
Yan Chen
Maite Alvarez
William Strober
Andrea Velardi
Judith A. Shizuru
Joy Y. Wu
Shigeru Chiba
Robert S. Negrin
Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
description Treg cells suppress peripheral immune responses, but their function in haematopoiesis is unclear. Here the authors show they modulate the bone marrow microenvironment to sustain haematopoietic stem cell-driven generation of mature B cells.
format article
author Antonio Pierini
Hidekazu Nishikii
Jeanette Baker
Takaharu Kimura
Hye-Sook Kwon
Yuqiong Pan
Yan Chen
Maite Alvarez
William Strober
Andrea Velardi
Judith A. Shizuru
Joy Y. Wu
Shigeru Chiba
Robert S. Negrin
author_facet Antonio Pierini
Hidekazu Nishikii
Jeanette Baker
Takaharu Kimura
Hye-Sook Kwon
Yuqiong Pan
Yan Chen
Maite Alvarez
William Strober
Andrea Velardi
Judith A. Shizuru
Joy Y. Wu
Shigeru Chiba
Robert S. Negrin
author_sort Antonio Pierini
title Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
title_short Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
title_full Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
title_fullStr Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
title_full_unstemmed Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
title_sort foxp3+ regulatory t cells maintain the bone marrow microenvironment for b cell lymphopoiesis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/d29f840a46334d1d870fa58393c51f4b
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