Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring

Tai-Ping Sun1,2,5, Hsiu-Li Shieh2, Congo Tak-Shing Ching1,2,5, Yan-Dong Yao3, Su-Hua Huang4, Chia-Ming Liu1, Wei-Hao Liu1, Chung-Yuan Chen21Graduate Institute of Biomedicine and Biomedical Technology, 2Department of Electrical Engineering, National Chi Nan University, Nantou, Taiwan, ROC; 3Departmen...

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Autores principales:	Tai-Ping Sun, Hsiu-Li Shieh, Congo Tak-Shing Ching, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d2a44e252f054445a46f72ad2298566d
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spelling	oai:doaj.org-article:d2a44e252f054445a46f72ad2298566d2021-12-02T08:08:34ZCarbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring1176-91141178-2013https://doaj.org/article/d2a44e252f054445a46f72ad2298566d2010-05-01T00:00:00Zhttp://www.dovepress.com/carbon-nanotube-composites-for-glucose-biosensor-incorporated-with-rev-a4359https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Tai-Ping Sun1,2,5, Hsiu-Li Shieh2, Congo Tak-Shing Ching1,2,5, Yan-Dong Yao3, Su-Hua Huang4, Chia-Ming Liu1, Wei-Hao Liu1, Chung-Yuan Chen21Graduate Institute of Biomedicine and Biomedical Technology, 2Department of Electrical Engineering, National Chi Nan University, Nantou, Taiwan, ROC; 3Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong; 4Department of Biotechnology, Asia University, Taichung, Taiwan, ROC; 5These authors contributed equally to this workAbstract: This study aims to develop an amperometric glucose biosensor, based on carbon nanotubes material for reverse iontophoresis, fabricated by immobilizing a mixture of glucose oxidase (GOD) and multiwalled carbon nanotubes (MWCNT) epoxy-composite, on a planar screen-printed carbon electrode. MWCNT was employed to ensure proper incorporation into the epoxy mixture and faster electron transfer between the GOD and the transducer. Results showed this biosensor possesses a low detection potential (+500 mV), good sensitivity (4 &mu;A/mM) and an excellent linear response range (r2 = 0.999; 0&ndash;4 mM) of glucose detection at +500 mV (versus Ag/AgCl). The response time of the biosensor was about 25 s. In addition, the biosensor could be used in conjunction with reverse iontophoresis technique. In an actual evaluation model, an excellent linear relationship (r2 = 0.986) was found between the glucose concentration of the actual model and the biosensor&rsquo;s current response. Thus, a glucose biosensor based on carbon nanotube composites and incorporated with reverse iontophoresis function was developed.Keywords: amperometric, carbon nanotubes, glucose monitoring, biosensors, reverse iontophoresis Tai-Ping SunHsiu-Li ShiehCongo Tak-Shing Chinget alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 343-349 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tai-Ping Sun Hsiu-Li Shieh Congo Tak-Shing Ching et al Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
description	Tai-Ping Sun1,2,5, Hsiu-Li Shieh2, Congo Tak-Shing Ching1,2,5, Yan-Dong Yao3, Su-Hua Huang4, Chia-Ming Liu1, Wei-Hao Liu1, Chung-Yuan Chen21Graduate Institute of Biomedicine and Biomedical Technology, 2Department of Electrical Engineering, National Chi Nan University, Nantou, Taiwan, ROC; 3Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong; 4Department of Biotechnology, Asia University, Taichung, Taiwan, ROC; 5These authors contributed equally to this workAbstract: This study aims to develop an amperometric glucose biosensor, based on carbon nanotubes material for reverse iontophoresis, fabricated by immobilizing a mixture of glucose oxidase (GOD) and multiwalled carbon nanotubes (MWCNT) epoxy-composite, on a planar screen-printed carbon electrode. MWCNT was employed to ensure proper incorporation into the epoxy mixture and faster electron transfer between the GOD and the transducer. Results showed this biosensor possesses a low detection potential (+500 mV), good sensitivity (4 &mu;A/mM) and an excellent linear response range (r2 = 0.999; 0&ndash;4 mM) of glucose detection at +500 mV (versus Ag/AgCl). The response time of the biosensor was about 25 s. In addition, the biosensor could be used in conjunction with reverse iontophoresis technique. In an actual evaluation model, an excellent linear relationship (r2 = 0.986) was found between the glucose concentration of the actual model and the biosensor&rsquo;s current response. Thus, a glucose biosensor based on carbon nanotube composites and incorporated with reverse iontophoresis function was developed.Keywords: amperometric, carbon nanotubes, glucose monitoring, biosensors, reverse iontophoresis
format	article
author	Tai-Ping Sun Hsiu-Li Shieh Congo Tak-Shing Ching et al
author_facet	Tai-Ping Sun Hsiu-Li Shieh Congo Tak-Shing Ching et al
author_sort	Tai-Ping Sun
title	Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
title_short	Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
title_full	Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
title_fullStr	Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
title_full_unstemmed	Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
title_sort	carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/d2a44e252f054445a46f72ad2298566d
work_keys_str_mv	AT taipingsun carbonnanotubecompositesforglucosebiosensorincorporatedwithreverseiontophoresisfunctionfornoninvasiveglucosemonitoring AT hsiulishieh carbonnanotubecompositesforglucosebiosensorincorporatedwithreverseiontophoresisfunctionfornoninvasiveglucosemonitoring AT congotakshingching carbonnanotubecompositesforglucosebiosensorincorporatedwithreverseiontophoresisfunctionfornoninvasiveglucosemonitoring AT etal carbonnanotubecompositesforglucosebiosensorincorporatedwithreverseiontophoresisfunctionfornoninvasiveglucosemonitoring
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Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring

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