Discovery of driver non-coding splice-site-creating mutations in cancer

Non-coding cancer driver mutations that induce splicing variants exist, but are largely unexplored. Here, the authors find these non-coding mutations in known pan-cancer driver genes and show that they create new exons and might interact with pre-existing potential splice sites.

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Autores principales:	Song Cao, Daniel Cui Zhou, Clara Oh, Reyka G. Jayasinghe, Yanyan Zhao, Christopher J. Yoon, Matthew A. Wyczalkowski, Matthew H. Bailey, Terrence Tsou, Qingsong Gao, Andrew Malone, Sheila Reynolds, Ilya Shmulevich, Michael C. Wendl, Feng Chen, Li Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2a72161fdd34e848ad4dc5d066b00b8
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spelling	oai:doaj.org-article:d2a72161fdd34e848ad4dc5d066b00b82021-12-02T14:42:48ZDiscovery of driver non-coding splice-site-creating mutations in cancer10.1038/s41467-020-19307-62041-1723https://doaj.org/article/d2a72161fdd34e848ad4dc5d066b00b82020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19307-6https://doaj.org/toc/2041-1723Non-coding cancer driver mutations that induce splicing variants exist, but are largely unexplored. Here, the authors find these non-coding mutations in known pan-cancer driver genes and show that they create new exons and might interact with pre-existing potential splice sites.Song CaoDaniel Cui ZhouClara OhReyka G. JayasingheYanyan ZhaoChristopher J. YoonMatthew A. WyczalkowskiMatthew H. BaileyTerrence TsouQingsong GaoAndrew MaloneSheila ReynoldsIlya ShmulevichMichael C. WendlFeng ChenLi DingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Song Cao Daniel Cui Zhou Clara Oh Reyka G. Jayasinghe Yanyan Zhao Christopher J. Yoon Matthew A. Wyczalkowski Matthew H. Bailey Terrence Tsou Qingsong Gao Andrew Malone Sheila Reynolds Ilya Shmulevich Michael C. Wendl Feng Chen Li Ding Discovery of driver non-coding splice-site-creating mutations in cancer
description	Non-coding cancer driver mutations that induce splicing variants exist, but are largely unexplored. Here, the authors find these non-coding mutations in known pan-cancer driver genes and show that they create new exons and might interact with pre-existing potential splice sites.
format	article
author	Song Cao Daniel Cui Zhou Clara Oh Reyka G. Jayasinghe Yanyan Zhao Christopher J. Yoon Matthew A. Wyczalkowski Matthew H. Bailey Terrence Tsou Qingsong Gao Andrew Malone Sheila Reynolds Ilya Shmulevich Michael C. Wendl Feng Chen Li Ding
author_facet	Song Cao Daniel Cui Zhou Clara Oh Reyka G. Jayasinghe Yanyan Zhao Christopher J. Yoon Matthew A. Wyczalkowski Matthew H. Bailey Terrence Tsou Qingsong Gao Andrew Malone Sheila Reynolds Ilya Shmulevich Michael C. Wendl Feng Chen Li Ding
author_sort	Song Cao
title	Discovery of driver non-coding splice-site-creating mutations in cancer
title_short	Discovery of driver non-coding splice-site-creating mutations in cancer
title_full	Discovery of driver non-coding splice-site-creating mutations in cancer
title_fullStr	Discovery of driver non-coding splice-site-creating mutations in cancer
title_full_unstemmed	Discovery of driver non-coding splice-site-creating mutations in cancer
title_sort	discovery of driver non-coding splice-site-creating mutations in cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d2a72161fdd34e848ad4dc5d066b00b8
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Discovery of driver non-coding splice-site-creating mutations in cancer

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