Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.

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Autores principales:	Melike Çağlayan, Julie K. Horton, Da-Peng Dai, Donna F. Stefanick, Samuel H. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2a81dca650b43be9b6e7c1748afddde
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spelling	oai:doaj.org-article:d2a81dca650b43be9b6e7c1748afddde2021-12-02T14:42:44ZOxidized nucleotide insertion by pol β confounds ligation during base excision repair10.1038/ncomms140452041-1723https://doaj.org/article/d2a81dca650b43be9b6e7c1748afddde2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14045https://doaj.org/toc/2041-1723Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.Melike ÇağlayanJulie K. HortonDa-Peng DaiDonna F. StefanickSamuel H. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melike Çağlayan Julie K. Horton Da-Peng Dai Donna F. Stefanick Samuel H. Wilson Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
description	Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.
format	article
author	Melike Çağlayan Julie K. Horton Da-Peng Dai Donna F. Stefanick Samuel H. Wilson
author_facet	Melike Çağlayan Julie K. Horton Da-Peng Dai Donna F. Stefanick Samuel H. Wilson
author_sort	Melike Çağlayan
title	Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
title_short	Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
title_full	Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
title_fullStr	Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
title_full_unstemmed	Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
title_sort	oxidized nucleotide insertion by pol β confounds ligation during base excision repair
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d2a81dca650b43be9b6e7c1748afddde
work_keys_str_mv	AT melikecaglayan oxidizednucleotideinsertionbypolbconfoundsligationduringbaseexcisionrepair AT juliekhorton oxidizednucleotideinsertionbypolbconfoundsligationduringbaseexcisionrepair AT dapengdai oxidizednucleotideinsertionbypolbconfoundsligationduringbaseexcisionrepair AT donnafstefanick oxidizednucleotideinsertionbypolbconfoundsligationduringbaseexcisionrepair AT samuelhwilson oxidizednucleotideinsertionbypolbconfoundsligationduringbaseexcisionrepair
_version_	1718389597202808832

Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

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