Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/d2a81dca650b43be9b6e7c1748afddde |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|