High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients

Objective: This study aims to evaluate plasma S100A9 levels in tuberculosis (TB) patients with admission to the ICU as a marker to predict the risk of death for pulmonary severe TB. Methods: This study enrolled 256 severe TB patients admitted to Beijing Chest Hospital from Jan to Dec 2019. The S100A...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qiuyue Liu, Ru Li, Qi Li, Baojian Luo, Jun Lin, Lingna Lyu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	S100A9 Intensive care unit Predictive factor Severe pulmonary tuberculosis Respiratory insufficiency Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/d2afa97a495542d3ad6bd997b1f40c92
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d2afa97a495542d3ad6bd997b1f40c92
record_format	dspace
spelling	oai:doaj.org-article:d2afa97a495542d3ad6bd997b1f40c922021-11-22T04:27:22ZHigh levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients2405-579410.1016/j.jctube.2021.100270https://doaj.org/article/d2afa97a495542d3ad6bd997b1f40c922021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405579421000590https://doaj.org/toc/2405-5794Objective: This study aims to evaluate plasma S100A9 levels in tuberculosis (TB) patients with admission to the ICU as a marker to predict the risk of death for pulmonary severe TB. Methods: This study enrolled 256 severe TB patients admitted to Beijing Chest Hospital from Jan to Dec 2019. The S100A9 levels were measured by ELISA. Standard clinical parameters were collected. The non-parametric Mann-Whitney test, t-test, and chi-square test were applied to statistical comparison. A multivariable analysis was performed to identify risk factors for death. Results: The plasma S100A9 levels were higher in non-survivors (25.88, 16.77–44.64) compared to survivors (15.51, 13.67–19.94). S100A9 performed better than Acute Physiology and Chronic Health Evaluation (APACHE II) score in predicting death, with AUC of 0.725, sensitivity of 65.5%, and specificity of 80.3%. By combining APACHE II score together with the S100A9 levels we got an AUC of 0.754 (95% CI 0.68 to 0.82) in predicting death. Lastly, S100A9 levels were significantly higher in patients with APACHE II score >17.5, sputum smear-positive, early death, and high cavitary lesions numbers, all of which were related to TB progression. Conclusion: Measurement and monitoring levels of plasma S100A9 in severe TB patients could facilitate the evaluation of patients with high risk at the early stage, which may help to improve the treatment outcome for TB patients.Qiuyue LiuRu LiQi LiBaojian LuoJun LinLingna LyuElsevierarticleS100A9Intensive care unitPredictive factorSevere pulmonary tuberculosisRespiratory insufficiencyDiseases of the respiratory systemRC705-779Infectious and parasitic diseasesRC109-216ENJournal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 25, Iss , Pp 100270- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	S100A9 Intensive care unit Predictive factor Severe pulmonary tuberculosis Respiratory insufficiency Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
spellingShingle	S100A9 Intensive care unit Predictive factor Severe pulmonary tuberculosis Respiratory insufficiency Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216 Qiuyue Liu Ru Li Qi Li Baojian Luo Jun Lin Lingna Lyu High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients
description	Objective: This study aims to evaluate plasma S100A9 levels in tuberculosis (TB) patients with admission to the ICU as a marker to predict the risk of death for pulmonary severe TB. Methods: This study enrolled 256 severe TB patients admitted to Beijing Chest Hospital from Jan to Dec 2019. The S100A9 levels were measured by ELISA. Standard clinical parameters were collected. The non-parametric Mann-Whitney test, t-test, and chi-square test were applied to statistical comparison. A multivariable analysis was performed to identify risk factors for death. Results: The plasma S100A9 levels were higher in non-survivors (25.88, 16.77–44.64) compared to survivors (15.51, 13.67–19.94). S100A9 performed better than Acute Physiology and Chronic Health Evaluation (APACHE II) score in predicting death, with AUC of 0.725, sensitivity of 65.5%, and specificity of 80.3%. By combining APACHE II score together with the S100A9 levels we got an AUC of 0.754 (95% CI 0.68 to 0.82) in predicting death. Lastly, S100A9 levels were significantly higher in patients with APACHE II score >17.5, sputum smear-positive, early death, and high cavitary lesions numbers, all of which were related to TB progression. Conclusion: Measurement and monitoring levels of plasma S100A9 in severe TB patients could facilitate the evaluation of patients with high risk at the early stage, which may help to improve the treatment outcome for TB patients.
format	article
author	Qiuyue Liu Ru Li Qi Li Baojian Luo Jun Lin Lingna Lyu
author_facet	Qiuyue Liu Ru Li Qi Li Baojian Luo Jun Lin Lingna Lyu
author_sort	Qiuyue Liu
title	High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients
title_short	High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients
title_full	High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients
title_fullStr	High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients
title_full_unstemmed	High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients
title_sort	high levels of plasma s100a9 at admission indicate an increased risk of death in severe tuberculosis patients
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d2afa97a495542d3ad6bd997b1f40c92
work_keys_str_mv	AT qiuyueliu highlevelsofplasmas100a9atadmissionindicateanincreasedriskofdeathinseveretuberculosispatients AT ruli highlevelsofplasmas100a9atadmissionindicateanincreasedriskofdeathinseveretuberculosispatients AT qili highlevelsofplasmas100a9atadmissionindicateanincreasedriskofdeathinseveretuberculosispatients AT baojianluo highlevelsofplasmas100a9atadmissionindicateanincreasedriskofdeathinseveretuberculosispatients AT junlin highlevelsofplasmas100a9atadmissionindicateanincreasedriskofdeathinseveretuberculosispatients AT lingnalyu highlevelsofplasmas100a9atadmissionindicateanincreasedriskofdeathinseveretuberculosispatients
_version_	1718418188763398144

High levels of plasma S100A9 at admission indicate an increased risk of death in severe tuberculosis patients

Ejemplares similares