Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

The mode of miRNA transfer between tumour-immune cells is usually via exosomes. Here, the authors show that an alternative mode of transfer whereby miR-375 from apoptotic tumour cells can be transferred to tumour-associated macrophages via CD36 receptor, which induces macrophage migration and infilt...

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Autores principales:	Ann-Christin Frank, Stefanie Ebersberger, Annika F. Fink, Sebastian Lampe, Andreas Weigert, Tobias Schmid, Ingo Ebersberger, Shahzad Nawaz Syed, Bernhard Brüne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2b11eaf9fd04b7eae86d20dd617388c
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spelling	oai:doaj.org-article:d2b11eaf9fd04b7eae86d20dd617388c2021-12-02T14:35:56ZApoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype10.1038/s41467-019-08989-22041-1723https://doaj.org/article/d2b11eaf9fd04b7eae86d20dd617388c2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08989-2https://doaj.org/toc/2041-1723The mode of miRNA transfer between tumour-immune cells is usually via exosomes. Here, the authors show that an alternative mode of transfer whereby miR-375 from apoptotic tumour cells can be transferred to tumour-associated macrophages via CD36 receptor, which induces macrophage migration and infiltration to the tumours.Ann-Christin FrankStefanie EbersbergerAnnika F. FinkSebastian LampeAndreas WeigertTobias SchmidIngo EbersbergerShahzad Nawaz SyedBernhard BrüneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ann-Christin Frank Stefanie Ebersberger Annika F. Fink Sebastian Lampe Andreas Weigert Tobias Schmid Ingo Ebersberger Shahzad Nawaz Syed Bernhard Brüne Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
description	The mode of miRNA transfer between tumour-immune cells is usually via exosomes. Here, the authors show that an alternative mode of transfer whereby miR-375 from apoptotic tumour cells can be transferred to tumour-associated macrophages via CD36 receptor, which induces macrophage migration and infiltration to the tumours.
format	article
author	Ann-Christin Frank Stefanie Ebersberger Annika F. Fink Sebastian Lampe Andreas Weigert Tobias Schmid Ingo Ebersberger Shahzad Nawaz Syed Bernhard Brüne
author_facet	Ann-Christin Frank Stefanie Ebersberger Annika F. Fink Sebastian Lampe Andreas Weigert Tobias Schmid Ingo Ebersberger Shahzad Nawaz Syed Bernhard Brüne
author_sort	Ann-Christin Frank
title	Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
title_short	Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
title_full	Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
title_fullStr	Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
title_full_unstemmed	Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
title_sort	apoptotic tumor cell-derived microrna-375 uses cd36 to alter the tumor-associated macrophage phenotype
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d2b11eaf9fd04b7eae86d20dd617388c
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Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

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