The Roles and Mechanisms of lncRNAs in Liver Fibrosis

Long non-coding RNAs (lncRNAs) can potentially regulate all aspects of cellular activity including differentiation and development, metabolism, proliferation, apoptosis, and activation, and benefited from advances in transcriptomic and genomic research techniques and database management technologies...

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Autores principales:	Zhifa Wang, Xiaoke Yang, Siyu Gui, Fan Yang, Zhuo Cao, Rong Cheng, Xiaowei Xia, Chuanying Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lncRNAs liver fibrosis ceRNAs HSCs therapeutic strategies Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d2b161c2a54e47398bd00e91a92ca947
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spelling	oai:doaj.org-article:d2b161c2a54e47398bd00e91a92ca9472021-11-30T18:42:03ZThe Roles and Mechanisms of lncRNAs in Liver Fibrosis1663-981210.3389/fphar.2021.779606https://doaj.org/article/d2b161c2a54e47398bd00e91a92ca9472021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.779606/fullhttps://doaj.org/toc/1663-9812Long non-coding RNAs (lncRNAs) can potentially regulate all aspects of cellular activity including differentiation and development, metabolism, proliferation, apoptosis, and activation, and benefited from advances in transcriptomic and genomic research techniques and database management technologies, its functions and mechanisms in physiological and pathological states have been widely reported. Liver fibrosis is typically characterized by a reversible wound healing response, often accompanied by an excessive accumulation of extracellular matrix. In recent years, a range of lncRNAs have been investigated and found to be involved in several cellular-level regulatory processes as competing endogenous RNAs (ceRNAs) that play an important role in the development of liver fibrosis. A variety of lncRNAs have also been shown to contribute to the altered cell cycle, proliferation profile associated with the accelerated development of liver fibrosis. This review aims to discuss the functions and mechanisms of lncRNAs in the development and regression of liver fibrosis, to explore the major lncRNAs involved in the signaling pathways regulating liver fibrosis, to elucidate the mechanisms mediated by lncRNA dysregulation and to provide new diagnostic and therapeutic strategies for liver fibrosis.Zhifa WangXiaoke YangSiyu GuiFan YangZhuo CaoRong ChengXiaowei XiaChuanying LiFrontiers Media S.A.articlelncRNAsliver fibrosisceRNAsHSCstherapeutic strategiesTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNAs liver fibrosis ceRNAs HSCs therapeutic strategies Therapeutics. Pharmacology RM1-950
spellingShingle	lncRNAs liver fibrosis ceRNAs HSCs therapeutic strategies Therapeutics. Pharmacology RM1-950 Zhifa Wang Xiaoke Yang Siyu Gui Fan Yang Zhuo Cao Rong Cheng Xiaowei Xia Chuanying Li The Roles and Mechanisms of lncRNAs in Liver Fibrosis
description	Long non-coding RNAs (lncRNAs) can potentially regulate all aspects of cellular activity including differentiation and development, metabolism, proliferation, apoptosis, and activation, and benefited from advances in transcriptomic and genomic research techniques and database management technologies, its functions and mechanisms in physiological and pathological states have been widely reported. Liver fibrosis is typically characterized by a reversible wound healing response, often accompanied by an excessive accumulation of extracellular matrix. In recent years, a range of lncRNAs have been investigated and found to be involved in several cellular-level regulatory processes as competing endogenous RNAs (ceRNAs) that play an important role in the development of liver fibrosis. A variety of lncRNAs have also been shown to contribute to the altered cell cycle, proliferation profile associated with the accelerated development of liver fibrosis. This review aims to discuss the functions and mechanisms of lncRNAs in the development and regression of liver fibrosis, to explore the major lncRNAs involved in the signaling pathways regulating liver fibrosis, to elucidate the mechanisms mediated by lncRNA dysregulation and to provide new diagnostic and therapeutic strategies for liver fibrosis.
format	article
author	Zhifa Wang Xiaoke Yang Siyu Gui Fan Yang Zhuo Cao Rong Cheng Xiaowei Xia Chuanying Li
author_facet	Zhifa Wang Xiaoke Yang Siyu Gui Fan Yang Zhuo Cao Rong Cheng Xiaowei Xia Chuanying Li
author_sort	Zhifa Wang
title	The Roles and Mechanisms of lncRNAs in Liver Fibrosis
title_short	The Roles and Mechanisms of lncRNAs in Liver Fibrosis
title_full	The Roles and Mechanisms of lncRNAs in Liver Fibrosis
title_fullStr	The Roles and Mechanisms of lncRNAs in Liver Fibrosis
title_full_unstemmed	The Roles and Mechanisms of lncRNAs in Liver Fibrosis
title_sort	roles and mechanisms of lncrnas in liver fibrosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d2b161c2a54e47398bd00e91a92ca947
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The Roles and Mechanisms of lncRNAs in Liver Fibrosis

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