Sex and region-specific effects of variable stress on microglia morphology

Major Depressive Disorder (MDD) is a common and debilitating mood disorder that is more prevalent in women than men. In humans, PET imaging of microglia activation is currently being explored as a potential biomarker of MDD and suicidal ideation. Stress is a trigger for many mood disorders, includin...

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Autores principales:	Mariya Tsyglakova, Alisa M. Huskey, Emily H. Hurst, Natalie M. Telep, Mary C. Wilding, Meghan E. Babington, Jennifer R. Rainville, Georgia E. Hodes
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d2b2d02aad254449980c85ee34a0c6cd
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spelling	oai:doaj.org-article:d2b2d02aad254449980c85ee34a0c6cd2021-11-12T04:47:57ZSex and region-specific effects of variable stress on microglia morphology2666-354610.1016/j.bbih.2021.100378https://doaj.org/article/d2b2d02aad254449980c85ee34a0c6cd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666354621001812https://doaj.org/toc/2666-3546Major Depressive Disorder (MDD) is a common and debilitating mood disorder that is more prevalent in women than men. In humans, PET imaging of microglia activation is currently being explored as a potential biomarker of MDD and suicidal ideation. Stress is a trigger for many mood disorders, including MDD. Microglial changes in morphology and activation state in response to stress has been reported in various brain regions, but most studies only examined male subjects. Here we report changes in microglia morphology in the nucleus accumbens (NAc) and subregions of the hippocampus (HPC) in both male and female mice following variable stress of 6 or 28 days in duration. Our data demonstrate that after 6 days of stress, microglia in the female NAc and dentate gyrus have a reduction in homeostatic associated morphology and an increase in primed microglia. After 28 days some of these sex specific stress effects were still present in microglia within the NAc but not the dentate gyrus. There were no effects of stress in either sex at either timepoint in CA1. In female mice, anti-inflammatory activation of microglia using rosiglitazone promoted sociability behavior after 6 days of stress. Furthermore, both drug and stress have impact on microglia morphology and activation state in the NAc. These data suggest that microglia morphology and activation state are altered by 6 days of variable stress in a region-specific manner and may contribute to, or potentially compensate for, the onset of stress susceptibility rather than impacting long term exposure to stress.Mariya TsyglakovaAlisa M. HuskeyEmily H. HurstNatalie M. TelepMary C. WildingMeghan E. BabingtonJennifer R. RainvilleGeorgia E. HodesElsevierarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain, Behavior, & Immunity - Health, Vol 18, Iss , Pp 100378- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Mariya Tsyglakova Alisa M. Huskey Emily H. Hurst Natalie M. Telep Mary C. Wilding Meghan E. Babington Jennifer R. Rainville Georgia E. Hodes Sex and region-specific effects of variable stress on microglia morphology
description	Major Depressive Disorder (MDD) is a common and debilitating mood disorder that is more prevalent in women than men. In humans, PET imaging of microglia activation is currently being explored as a potential biomarker of MDD and suicidal ideation. Stress is a trigger for many mood disorders, including MDD. Microglial changes in morphology and activation state in response to stress has been reported in various brain regions, but most studies only examined male subjects. Here we report changes in microglia morphology in the nucleus accumbens (NAc) and subregions of the hippocampus (HPC) in both male and female mice following variable stress of 6 or 28 days in duration. Our data demonstrate that after 6 days of stress, microglia in the female NAc and dentate gyrus have a reduction in homeostatic associated morphology and an increase in primed microglia. After 28 days some of these sex specific stress effects were still present in microglia within the NAc but not the dentate gyrus. There were no effects of stress in either sex at either timepoint in CA1. In female mice, anti-inflammatory activation of microglia using rosiglitazone promoted sociability behavior after 6 days of stress. Furthermore, both drug and stress have impact on microglia morphology and activation state in the NAc. These data suggest that microglia morphology and activation state are altered by 6 days of variable stress in a region-specific manner and may contribute to, or potentially compensate for, the onset of stress susceptibility rather than impacting long term exposure to stress.
format	article
author	Mariya Tsyglakova Alisa M. Huskey Emily H. Hurst Natalie M. Telep Mary C. Wilding Meghan E. Babington Jennifer R. Rainville Georgia E. Hodes
author_facet	Mariya Tsyglakova Alisa M. Huskey Emily H. Hurst Natalie M. Telep Mary C. Wilding Meghan E. Babington Jennifer R. Rainville Georgia E. Hodes
author_sort	Mariya Tsyglakova
title	Sex and region-specific effects of variable stress on microglia morphology
title_short	Sex and region-specific effects of variable stress on microglia morphology
title_full	Sex and region-specific effects of variable stress on microglia morphology
title_fullStr	Sex and region-specific effects of variable stress on microglia morphology
title_full_unstemmed	Sex and region-specific effects of variable stress on microglia morphology
title_sort	sex and region-specific effects of variable stress on microglia morphology
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d2b2d02aad254449980c85ee34a0c6cd
work_keys_str_mv	AT mariyatsyglakova sexandregionspecificeffectsofvariablestressonmicrogliamorphology AT alisamhuskey sexandregionspecificeffectsofvariablestressonmicrogliamorphology AT emilyhhurst sexandregionspecificeffectsofvariablestressonmicrogliamorphology AT nataliemtelep sexandregionspecificeffectsofvariablestressonmicrogliamorphology AT marycwilding sexandregionspecificeffectsofvariablestressonmicrogliamorphology AT meghanebabington sexandregionspecificeffectsofvariablestressonmicrogliamorphology AT jenniferrrainville sexandregionspecificeffectsofvariablestressonmicrogliamorphology AT georgiaehodes sexandregionspecificeffectsofvariablestressonmicrogliamorphology
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Sex and region-specific effects of variable stress on microglia morphology

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